Peptidases • Zoopagomycota
Annotations/GenomesBasme2finSCCoemoj1Coere1Coespi1Conco1Conth1DimcrSC1Kicala1Linpe1Marpt1Pipcy3_1Rambr1SmicuMNP_2SmiculW2_1Smimuc2Synfus1Synplu1Synps1Thasp1Zancul2Zoorad1TotalAnnotation Description
Merops
5362062042234393502311942722551413693282812203252852292402474906,065
18646223446212572332354103Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1123119Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
3111111131122143131133Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
332120202217211629161122241813221715201516408Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
634456433548544665585103Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
722211332523111422246Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111112111317Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2215Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
123Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2111128Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
154457653532347443234598Families of peptidase inhibitors not assigned to clans
112
123
516
314
1113
2215
33
11
312111131115
2112121511235112132
211111111121122120Families of metallopeptidases not assigned to clans
53221822291823142928121912116383525351148508Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
73011157436689Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
8243112333165321117764Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
5334233355249732325477Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
119888787878911977136586170Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
3381010402511121712822242622191111101712360Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
306565954764743356454128Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111111111113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
1113Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
4333455544263254533376Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by two cobalt ions ligated by Glu, Glu, His, His, Asp
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
221814187555101923254373838361384461182704Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
362218202419212221211320422821231925181920472Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1044521325543811155151296Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11211112111121219Serine or threonine nucleophile; N-terminal nucleophile
73342462920144643181815674626341734510Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9138494990694143616631627156475757523942701,181Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
234184839Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
65531064336379105544247111Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2114Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1112212211211121111126Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11114Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
5313566232442225734675Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
114118Families of peptidases of unknown catalytic mechanism not assigned to clans
2111111111121211111123
28131417172017121515816242110161316161212332
132111110
11
1113
141272724