Peptidases • Thozetella sp. PMI_491 v2.0
Annotations/GenomesChain1ConPMI546Conli1Conlig1Crypa2Maggr1Neucr2Ophpc1Phaal1ThoPMI491_1TotalAnnotation Description
Merops
4273423293733773372423589883,773
282522252718192067251Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11114Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
44661254840Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by Asp and His; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
251517152915162441197Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
34444334635Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1112211110Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111111210Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111117Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1043481241854Water nucleophile; water bound by Gln and Glu; all endopeptidases
211111411Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
34443434534Families of peptidase inhibitors not assigned to clans
1113
11
12121232216
28441614939
213
223233231131Families of metallopeptidases not assigned to clans
211217201323121939176Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
13221423321Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
22212222217Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
109691081091384Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
201618212219142350203Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
2081113156102150154Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1124Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
112Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
33333343227Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11111128Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
212311120Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
242326282421232533227Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
477734271455Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
2111211312Serine or threonine nucleophile; N-terminal nucleophile
123Families of serine peptidases not assigned to clans
32222125202082567240Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
176126114135137120711064431,428Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
9781083573491Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
13233322322Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11112111110Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
121112311Serine nucleophile; catalytic residues in the order Ser, Glu, His
24354342431Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
3111172117Families of peptidases of unknown catalytic mechanism not assigned to clans
11111121110
612981511131515104
112
112
333338141341