Peptidases • Pezizomycetes
Annotations/GenomesAscim1Ascni1Calful1Chove1Geocar1Gyresc1Kalpfe1Morco1Morimp1Morsny1Pezech1Plemel1Pyrco1Rhiund1Sarco1Sphbr2Terbo2Tercla1Tirniv1Trihyb1Tripra1Tubae1Tubbor1Tubma1Tubme1v2Wilmi1TotalAnnotation Description
Merops
2181771882172252102092062091971763512192462582311891851762252201981951842175,326
5569775445621612912435855347167Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
2114Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
4336231123975744444312486Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
19182523282426222122232727252121202824232320232923585Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
222222422223923222232132262Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
21321112122111122131121338Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111111111111111111222Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
211111211112Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111111111111111111121Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2125Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
333334445453463344433332490Families of peptidase inhibitors not assigned to clans
11114
11
1124
2311111112111121221221132
313343343336342311244232373
215112122217222311121121147Families of metallopeptidases not assigned to clans
1561212122515161812132113131421101010171515131014352Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
21111111211221111122Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11114Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
2111213111112122122111233Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
65410865666676876756777577160Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
121311101312131211121222151519121110101916108918325Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
56359655556116887655655635146Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
4458544344444445444446434107Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
21111114111212111124Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
18201819182120202020182221192322201818202022161821492Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
4435465897362861424343753116Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111115Serine or threonine nucleophile; N-terminal nucleophile
228812771087781891412111112610758510242Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
6141475761515260585432116496277564141405965594651581,394Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
21152331211224Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
431323433333333433332243273Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
112122211222121222212211139Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order Ser, Glu, His
122222223244233432321211156Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11114Families of peptidases of unknown catalytic mechanism not assigned to clans
11111211111321122111111130
10151211131213121212111513141120161412161712121213330
11114
111317
3425322323143471111224103376