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PFAM Domains • Lobaria pulmonaria Spain extracted metagenome v1.0
Annotations/GenomesLobpul1LobpulAf1LobpulSc1LobpulSp1LobpulSw1TotalAnnotation Description
PFAMs
10,90010,85510,91310,89810,91854,484
5555535555273ATPase family associated with various cellular activities (AAA)
3433343134166ABC transporter
4444420ATP synthase alpha/beta family, nucleotide-binding domain
161616161680Elongation factor Tu GTP binding domain
8878738Helix-loop-helix DNA-binding domain
3333315Hsp20/alpha crystallin family
161616171681Hsp70 protein
7777735KH domain
141414141470SH3 domain
101010101050Actin
10111492117123547Ankyrin repeat
111115PAN domain
7777735ADP-ribosylation factor family
2725272727133Eukaryotic aspartyl protease
4444420Cyclic nucleotide-binding domain
111115Cytochrome c
222219Double-stranded RNA binding motif
3333214EF hand
10998945Glutathione S-transferase, C-terminal domain
111115Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
3444419Homeodomain
2222210lactate/malate dehydrogenase, NAD binding domain
5555525Myosin head (motor domain)
205196197199197994Cytochrome P450
172170166164169841Protein kinase domain
121212121260Pyridine nucleotide-disulphide oxidoreductase
2525252525125Ras family
121212121260Response regulator receiver domain
2233313RNase H
5050484848244RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11Reverse transcriptase (RNA-dependent DNA polymerase)
3233213Copper/zinc superoxide dismutase (SODC)
2222210Iron/manganese superoxide dismutases, alpha-hairpin domain
1921221822102Subtilase family
3334363434171Sugar (and other) transporter
8888840Thioredoxin
3333315Tubulin/FtsZ family, GTPase domain
4232213von Willebrand factor type A domain
3038323438172Zinc finger, C2H2 type
2322312Zinc finger, C3HC4 type (RING finger)
111614151369Zinc knuckle
3333315Protein-tyrosine phosphatase
9488918789449short chain dehydrogenase
5351525252260Zinc-binding dehydrogenase
5555525Thiolase, N-terminal domain
4439423941205Beta-ketoacyl synthase, N-terminal domain
22222102Fe-2S iron-sulfur cluster binding domain
111115Enolase, C-terminal TIM barrel domain
8888840Glutamine amidotransferase class-I
101010101050TCP-1/cpn60 chaperonin family
4444420Glutamine synthetase, catalytic domain
2222210Triosephosphate isomerase
171717171785E1-E2 ATPase
8778737Core histone H2A/H2B/H3/H4
3333315Alpha amylase, catalytic domain
2222210Phorbol esters/diacylglycerol binding domain (C1 domain)
5656527Bacterial transferase hexapeptide (six repeats)
5555525tRNA synthetases class I (I, L, M and V)
8888840Cyclin, N-terminal domain
161515161577Carboxylesterase family
4444420DNA polymerase family B
3333315ATP synthase subunit C
3333315Peroxidase
8887839Beta-lactamase
5556526C-5 cytosine-specific DNA methylase
2725272525129Calcineurin-like phosphoesterase
9898943Cellulase (glycosyl hydrolase family 5)
8878839tRNA synthetases class II (D, K and N)
3837373737186Mitochondrial carrier protein
171617171683Aminotransferase class I and II
4444420Phosphoribosyl transferase domain
101010101050Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
111115Phosphoglycerate kinase
122229Ribosomal protein S4/S9 N-terminal domain
2222210Ribosomal protein S12/S23
111115Bacterial regulatory helix-turn-helix proteins, AraC family
111115Chaperonin 10 Kd subunit
101010101050C2 domain
9999945PH domain
111212131361bZIP transcription factor
131313131567Aldehyde dehydrogenase family
9394969893474Fungal Zn(2)-Cys(6) binuclear cluster domain
181818181890Cytochrome b5-like Heme/Steroid binding domain
3333315Oxidoreductase molybdopterin binding domain
7777735Oxidoreductase NAD-binding domain
3535353535175SNF2 family N-terminal domain
2222210Ribosomal protein S7p/S5e
2425252525124Ubiquitin-conjugating enzyme
7777735Isocitrate/isopropylmalate dehydrogenase
2222210Ribosomal Proteins L2, RNA binding domain
111115Hsp90 protein
2222210Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
111115Dihydrofolate reductase
6665629Chitin recognition protein
3333315Cysteine-rich secretory protein family
111115Ribosomal protein S3, C-terminal domain
4444420Cupin
2222210Annexin
33333152-oxoacid dehydrogenases acyltransferase (catalytic domain)
5555525Catalase
111115Disintegrin
4444420UDP-glucoronosyl and UDP-glucosyl transferase
5555525Aminotransferase class-III
2222210Ribosomal protein S19
111115DNA gyrase B
4444420Thiamine pyrophosphate enzyme, central domain
3333315Lyase
3333315Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
111115Adenylate and Guanylate cyclase catalytic domain
111115ATP synthase delta (OSCP) subunit
2222210Orotidine 5'-phosphate decarboxylase / HUMPS family
211116Indole-3-glycerol phosphate synthase
98912846Aromatic amino acid lyase
111115Pyruvate kinase, barrel domain
101010101050Kinesin motor domain
3029292829145DnaJ domain
151515151575Proteasome subunit
6666630Major intrinsic protein
111115ATP synthase
1111153'5'-cyclic nucleotide phosphodiesterase
111115Profilin
2222210Ribosomal protein L22p/L17e
4444420Ribosomal protein L14p/L23e
111111111155Ubiquitin family
4444420Cofilin/tropomyosin-type actin-binding protein
333331514-3-3 protein
2222210Alkaline phosphatase
2222210Zinc carboxypeptidase
2828282728139Aldo/keto reductase family
131112131160Myb-like DNA-binding domain
4444420Forkhead domain
2222210Glycosyl hydrolases family 32 N-terminal domain
2222210Ribosomal protein L16p/L10e
2222210Ribosomal protein S14p/S29e
3333315FKBP-type peptidyl-prolyl cis-trans isomerase
111115Glutathione peroxidase
5555525Flavodoxin
111115Calreticulin family
141414141470Common central domain of tyrosinase
8988841Aminotransferase class-V
111115Ribonucleotide reductase, small chain
5856525254272DEAD/DEAH box helicase
8994918995458Helicase conserved C-terminal domain
111115EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
2222210Ribosomal protein L23
2222210Pyridoxal-dependent decarboxylase, C-terminal sheet domain
2222210Ribosomal protein L5
7777735Pyridoxal-dependent decarboxylase conserved domain
6566528Citrate synthase, C-terminal domain
5454422GHMP kinases N terminal domain
6666630Biotin carboxylase, N-terminal domain
111115Tryptophan synthase alpha chain
9999945Pyridoxal-phosphate dependent enzyme
131313131365NUDIX domain
8777736pfkB family carbohydrate kinase
2222210Luciferase-like monooxygenase
2222210Ribosomal protein L3
2222210Ribosomal protein L11, RNA binding domain
131313131365Histidine phosphatase superfamily (branch 1)
111115Thymidylate synthase
111115Lipoxygenase
4444420ATP synthase alpha/beta chain, C terminal domain
5555525Calponin homology (CH) domain
3333315Glutamine amidotransferases class-II
2222210Ribosomal protein S15
111115Thaumatin family
111115Fructose-1-6-bisphosphatase, N-terminal domain
111115Ribonucleotide reductase, all-alpha domain
2222210Ribosomal protein S2
2222210SRF-type transcription factor (DNA-binding and dimerisation domain)
6666731GATA zinc finger
111111111155Amino acid permease
5544422Prolyl oligopeptidase family
2222210Ribosomal protein L30p/L7e
8888840Histidine phosphatase superfamily (branch 2)
111115Respiratory-chain NADH dehydrogenase, 30 Kd subunit
4444420Aconitase family (aconitate hydratase)
3333315Glycosyl hydrolases family 17
2222210Ribosomal protein S5, N-terminal domain
111115Nucleoside diphosphate kinase
2222210Tetraspanin family
2222210Ribosomal protein S10p/S20e
4434419Arrestin (or S-antigen), N-terminal domain
111115Phosphoglucose isomerase
111115Carbohydrate phosphorylase
111115SecY translocase
111115Respiratory-chain NADH dehydrogenase, 49 Kd subunit
2222210Ribosomal protein L6
8979942Polyprenyl synthetase
3333315Hexokinase
131313131365Dynamin family
111115Transcription factor TFIID (or TATA-binding protein, TBP)
2222210Rieske [2Fe-2S] domain
111115Phytochrome region
7777735Biotin-requiring enzyme
221128Phosphofructokinase
2222210Ribosomal protein S17
111115Hydroxymethylglutaryl-coenzyme A reductase
3333315FGGY family of carbohydrate kinases, N-terminal domain
101111111154Enoyl-CoA hydratase/isomerase
2222210Ribosomal protein S9/S16
2222210Transcription factor TFIIB repeat
8888840Cytidine and deoxycytidylate deaminase zinc-binding region
111115Molybdopterin oxidoreductase
8556630Chromo (CHRromatin Organisation MOdifier) domain
2222210Phosphatidylinositol-specific phospholipase C, Y domain
3333315Phosphatidylinositol-specific phospholipase C, X domain
6666630D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
222219Malic enzyme, N-terminal domain
1111156-phosphogluconate dehydrogenase, C-terminal domain
9999945Multicopper oxidase
111112121157WW domain
212218Ribosomal RNA adenine dimethylase
111115Yeast PIR protein repeat
129129119117121615WD domain, G-beta repeat
4444420Heavy-metal-associated domain
4444420Adenylate kinase
3333315Phosphoglucomutase/phosphomannomutase, C-terminal domain
2222210Ribosomal protein S8
2222210Ribosomal protein S11
4444420LIM domain
3333315Regulator of chromosome condensation (RCC1) repeat
2222210Ribosomal protein S13/S18
2222210chorismate binding enzyme
233331460s Acidic ribosomal protein
3333416Prenyltransferase and squalene oxidase repeat
4444420Protein kinase C terminal domain
111115Single-strand binding protein family
111115S-adenosylmethionine synthetase, N-terminal domain
7777735Bromodomain
7777735Acyl-CoA dehydrogenase, C-terminal domain
151515151575Ubiquitin carboxyl-terminal hydrolase
111115Ribosomal protein L36
111115Ribonuclease T2 family
3333315HSF-type DNA-binding
2222210SRP54-type protein, GTPase domain
111115Urease alpha-subunit, N-terminal domain
141414151471Serine carboxypeptidase
7777735Phosphatidylinositol 3- and 4-kinase
111115Transketolase, thiamine diphosphate binding domain
3334316Inositol monophosphatase family
4444420Glutaredoxin
2222210Isocitrate lyase family
3333214Serine hydroxymethyltransferase
2222210Iron-containing alcohol dehydrogenase
2222210Ribosomal protein L10
111115KOW motif
111115Ribosomal protein L34
111115Ribosomal protein L33
4444420RF-1 domain
3333315Sodium:solute symporter family
111115Imidazoleglycerol-phosphate dehydratase
111115DNA polymerase family A
111115IMP dehydrogenase / GMP reductase domain
2222210Glucose-6-phosphate dehydrogenase, NAD binding domain
6666630Protein phosphatase 2C
3323314Nucleotidyl transferase
2222210Carbonic anhydrase
2322312Phosphoribulokinase / Uridine kinase family
8888840Fatty acid desaturase
6666630MutS domain V
111115Delta-aminolevulinic acid dehydratase
4444420Arginase family
6666630MCM P-loop domain
3333315Squalene/phytoene synthase
101212111257FHA domain
5251525252259AMP-binding enzyme
6666630G-protein alpha subunit
8999944HMG (high mobility group) box
9999945His Kinase A (phospho-acceptor) domain
4444420Armadillo/beta-catenin-like repeat
161918141784Tetratricopeptide repeat
3333315Ion transport protein
111115DNA gyrase/topoisomerase IV, subunit A
8787737BRCA1 C Terminus (BRCT) domain
3333315Glycosyl transferases group 1
2222311Glycosyl transferase family 2
3333315SAM domain (Sterile alpha motif)
111115linker histone H1 and H5 family
111115Ribosomal protein L7/L12 C-terminal domain
2222210ribonuclease
111115Urease, gamma subunit
3333315CoA-ligase
5952555754277Phosphopantetheine attachment site
2222210Formyl transferase
7777735Metallopeptidase family M24
4444420Leucine Rich Repeat
8787737alpha/beta hydrolase fold
3333315RNA polymerase Rpb2, domain 6
3444419PB1 domain
2222210Staphylococcal nuclease homologue
121212131261Rab-GTPase-TBC domain
111115Tudor domain
111115WH1 domain
5445422Zinc finger, ZZ type
221218HRDC domain
8888840CBS domain
2222210Ribosomal protein L13
2222210Ribosomal protein L4/L1 family
111115Clp protease
4444420S1 RNA binding domain
111115HIUase/Transthyretin family
2222210AhpC/TSA family
6566528tRNA synthetases class I (W and Y)
2222210UvrD/REP helicase N-terminal domain
7777735Rhodanese-like domain
2222210Universal stress protein family
161516161679Acetyltransferase (GNAT) family
111115SecE/Sec61-gamma subunits of protein translocation complex
111115C-terminal regulatory domain of Threonine dehydratase
2222210AIR synthase related protein, N-terminal domain
7777735tRNA synthetase class II core domain (G, H, P, S and T)
111115SpoU rRNA Methylase family
2222210Tetrapyrrole (Corrin/Porphyrin) Methylases
111115Glycosyl transferase family, a/b domain
11PDZ domain
3333315Class II Aldolase and Adducin N-terminal domain
4444420Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
5555525Fes/CIP4, and EFC/F-BAR homology domain
3333315IQ calmodulin-binding motif
2222210Phosphoinositide 3-kinase family, accessory domain (PIK domain)
2222210Phospholipase D Active site motif
7777735Regulator of G protein signaling domain
3333315GTPase-activator protein for Ras-like GTPase
4444420RasGEF domain
4444420RasGEF N-terminal motif
9999945RhoGAP domain
6777734RhoGEF domain
7877736SPRY domain
3333315RNA polymerase Rpb1, domain 2
111115Guanylate kinase
3333315Gelsolin repeat
3455421UBA/TS-N domain
141313141367PHD-finger
111115GGL domain
6666630HECT-domain (ubiquitin-transferase)
111115Helix-hairpin-helix motif
111115MSP (Major sperm protein) domain
4444420Ribonuclease III domain
4444420Region in Clathrin and VPS
3333315RanBP1 domain
2222210PPIC-type PPIASE domain
2222210Zn-finger in Ran binding protein and others
7876634Zinc finger C-x8-C-x5-C-x3-H type (and similar)
122229Poly(ADP-ribose) polymerase catalytic domain
111115Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
181717181686F-box domain
111115Elongation factor 1 gamma, conserved domain
2222210Calpain family cysteine protease
2222210Copper fist DNA binding domain
4444420CRAL/TRIO domain
2830292829144BTB/POZ domain
111115Ricin-type beta-trefoil lectin domain
111115Inhibitor of Apoptosis domain
4444420Voltage gated chloride channel
4142516Caspase domain
3333315GDSL-like Lipase/Acylhydrolase
111115Poly-adenylate binding protein, unique domain
121212121260ABC transporter transmembrane region
4444420FAD binding domain
151515151676Condensation domain
111115S-adenosyl-L-homocysteine hydrolase, NAD binding domain
111115HAMP domain
2222210ribosomal L5P family C-terminus
6666630Insulinase (Peptidase family M16)
3333315Dehydrogenase E1 component
111115Lumazine binding domain
6666630Elongation factor G C-terminus
5555525HMGL-like
4444420DnaJ central domain
111115Starch binding domain
3333315Ribosomal protein L1p/L10e family
5555525Cation transporting ATPase, C-terminus
7777735Cation transporter/ATPase, N-terminus
111115dUTPase
4444420Aconitase C-terminal domain
4444420Amino acid kinase family
211116N-(5'phosphoribosyl)anthranilate (PRA) isomerase
4339414039202Acyl transferase domain
111115Urease beta subunit
111115Dihydrodipicolinate synthetase family
141414141470haloacid dehalogenase-like hydrolase
3333315Glycosyl hydrolases family 2
111111101154Glycosyl hydrolases family 18
111115Proliferating cell nuclear antigen, N-terminal domain
2222210Translation initiation factor IF-3, C-terminal domain
111115Acylphosphatase
111115Adenylosuccinate synthetase
111115Asparaginase, N-terminal
3333315Peptidase S24-like
111115Inorganic pyrophosphatase
6666630Glycosyl hydrolases family 16
111115Glycosyl hydrolases family 15
2222210NADH:flavin oxidoreductase / NADH oxidase family
1111153-hydroxyacyl-CoA dehydrogenase, C-terminal domain
2222210Glycosyl hydrolase family 20, catalytic domain
4444420HhH-GPD superfamily base excision DNA repair protein
111115AIR carboxylase
2325232323117GMC oxidoreductase
2222210Asparagine synthase
9898842Septin
111115EF-1 guanine nucleotide exchange domain
111115Homoserine dehydrogenase
3333315Flavin-binding monooxygenase-like
3333315tRNA synthetases class I (E and Q), catalytic domain
111115tRNA synthetases class I (R)
5545524XPG N-terminal domain
810109946Metallo-beta-lactamase superfamily
4444420F5/8 type C domain
3333315Choline/Carnitine o-acyltransferase
111115Putative esterase
111115Ferrochelatase
2222210Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
122229Arginosuccinate synthase
111115Electron transfer flavoprotein FAD-binding domain
3333315RNB domain
2222210Dioxygenase
3333315CNH domain
2222210Diacylglycerol kinase catalytic domain
7777735Dual specificity phosphatase, catalytic domain
2222210P21-Rho-binding domain
131313131365PX domain
3333315Ras association (RalGDS/AF-6) domain
6666630UBX domain
4444420VHS domain
111115Phosphoinositide 3-kinase C2
222219DAHP synthetase I family
5555525Carbon-nitrogen hydrolase
122218N-acetyltransferase
2222210Prephenate dehydratase
3333315Syntaxin
4444420Pumilio-family RNA binding repeat
5655526Histone-like transcription factor (CBF/NF-Y) and archaeal histone
111115Pterin binding enzyme
2222210ER lumen protein retaining receptor
2222210tRNA N6-adenosine threonylcarbamoyltransferase
111115Histidinol dehydrogenase
4444420impB/mucB/samB family
111115Ribosomal L15
3333315Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
111115Ribosomal L28 family
111115Ribosomal L29 protein
111115Ribosomal L39 protein
111115Ribosomal S17
111115Ribulose-phosphate 3 epimerase family
111115Translationally controlled tumour protein
111115RNA pseudouridylate synthase
4444420Histone deacetylase domain
112116POT family
111115PWWP domain
181718181889SET domain
6666630Isochorismatase family
111115Permease family
111115Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
4444420XPG I-region
3333315DNA photolyase
111115NlpC/P60 family
2222210Nitroreductase family
111115Sulfatase
1111156,7-dimethyl-8-ribityllumazine synthase
111115Ribosomal protein S16
2222210Acyl CoA binding protein
8888840Cullin family
2322312FAD binding domain
3635383536180O-methyltransferase domain
4444420EamA-like transporter family
8888840ThiF family
111115Ribosomal family S4e
2222210Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
3333315Ammonium Transporter Family
5555525Sulfate permease family
2222210MATH domain
2222210Dehydratase family
111115Transaldolase/Fructose-6-phosphate aldolase
2222210Mechanosensitive ion channel
2222210GTP cyclohydrolase II
1111153,4-dihydroxy-2-butanone 4-phosphate synthase
4444420Adaptor complexes medium subunit family
7777735Exonuclease
111115Dipeptidyl peptidase IV (DPP IV) N-terminal region
4456543852244NB-ARC domain
5555525Glycosyl hydrolase family 3 N terminal domain
111115Ribosomal protein L44
111115Sodium:sulfate symporter transmembrane region
111115DNA-dependent RNA polymerase
111115FAD binding domain in molybdopterin dehydrogenase
111115Glycosyl transferase family 4
2222210HCO3- transporter family
2222210Nucleosome assembly protein (NAP)
4444420Synaptobrevin
111115GMP synthase C terminal domain
111115Phage lysozyme
5555525Adenosine/AMP deaminase
11Barwin family
5555525Oxidoreductase FAD-binding domain
11911111052Thioesterase domain
2222210Histidine biosynthesis protein
111115UDP-glucose/GDP-mannose dehydrogenase family, central domain
2222210Carbamoyl-phosphate synthase small chain, CPSase domain
111115PAS fold
2222210Probable molybdopterin binding domain
4444420Sec1 family
2222210GDP dissociation inhibitor
7777735Sodium/hydrogen exchanger family
2222210RNA polymerase Rpb3/RpoA insert domain
4444420Initiation factor 2 subunit family
2222210Electron transfer flavoprotein domain
111115Uricase
111115Ribosomal S3Ae family
111115Ribosomal L27 protein
111115GTP1/OBG
2322211Gamma-glutamyltranspeptidase
111115Ribosomal L40e family
111115GrpE
2222210TatD related DNase
2222210Inhibitor of apoptosis-promoting Bax1
111115Eukaryotic DNA topoisomerase I, catalytic core
101010101050Dynamin central region
1111156-O-methylguanine DNA methyltransferase, DNA binding domain
2222210Bacteriorhodopsin-like protein
2222210Carboxyl transferase domain
171516171681UbiA prenyltransferase family
1113DegT/DnrJ/EryC1/StrS aminotransferase family
3333315Endoribonuclease L-PSP
1681018961Phosphorylase superfamily
7777634Cys/Met metabolism PLP-dependent enzyme
2222210Glycosyl hydrolases family 31
111115NADH ubiquinone oxidoreductase, 20 Kd subunit
11101191152ABC-2 type transporter
2222210Bestrophin, RFP-TM, chloride channel
7777735Amino-transferase class IV
5555525CDP-alcohol phosphatidyltransferase
111115Calpain large subunit, domain III
4444420ATP dependent DNA ligase domain
4444420FMN-dependent dehydrogenase
2222210Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
67667323-beta hydroxysteroid dehydrogenase/isomerase family
111115Glycosyl hydrolases family 38 N-terminal domain
2222210Nitrite and sulphite reductase 4Fe-4S domain
3333315Cutinase
111115Ribosomal protein S18
111115Clathrin light chain
111115Galactose-1-phosphate uridyl transferase, N-terminal domain
5555525Ubiquitin carboxyl-terminal hydrolase, family 1
111115Ribosomal protein S19e
111115Ribosomal protein S6e
6656629Transcription factor S-II (TFIIS)
111115Omp85 superfamily domain
4444420emp24/gp25L/p24 family/GOLD
111115NifU-like domain
111115Cyclin-dependent kinase regulatory subunit
3223212Asparaginase
111115F-actin capping protein, beta subunit
2222210Fructose-bisphosphate aldolase class-II
3333315Semialdehyde dehydrogenase, NAD binding domain
3333315DNA mismatch repair protein, C-terminal domain
111115Dephospho-CoA kinase
3334316MAPEG family
111115G10 protein
111115Succinate dehydrogenase/Fumarate reductase transmembrane subunit
221128DNA topoisomerase
111115Glucose inhibited division protein A
111115Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
2222210RNA 3'-terminal phosphate cyclase
66666303' exoribonuclease family, domain 1
111115tRNA-splicing ligase RtcB
111115tRNA pseudouridine synthase D (TruD)
111115Coenzyme A transferase
5555525SPFH domain / Band 7 family
3333315Cytidylyltransferase family
111115Formamidopyrimidine-DNA glycosylase N-terminal domain
2222210GDA1/CD39 (nucleoside phosphatase) family
2222210GNS1/SUR4 family
111115Hydroxymethylglutaryl-coenzyme A synthase N terminal
3333