LOCUS       scaffold_578            9895 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  .
ACCESSION   scaffold_578
VERSION     scaffold_578
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2025-04-15 22:57:13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9895
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9895
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1228:6365]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="30000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1229..6365
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="30000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..9895
                     /SMILES="C([*])C(-O)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9895
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     CDS             join(1229..1598,1642..4420,4547..6365)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-377). E-value:
                     4.3e-111. Score: 363.7. Matches aSDomain:
                     nrpspksdomains_10603_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (478-760). E-value: 4.2e-54.
                     Score: 175.8. Matches aSDomain:
                     nrpspksdomains_10603_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (866-985). E-value: 1.1e-08.
                     Score: 27.5. Matches aSDomain:
                     nrpspksdomains_10603_PKS_DH.1"
                     /NRPS_PKS="Domain: PP-binding (1162-1215). E-value:
                     1.2e-09. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_10603_PP-binding.1"
                     /NRPS_PKS="Domain: cMT (1469-1642). E-value: 4.8e-56.
                     Score: 181.4. Matches aSDomain: nrpspksdomains_10603_cMT.1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 67.6; E-value:
                     1.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="10603"
                     /sec_met_domain="itr_KS (E-value: 2.3e-116, bitscore:
                     376.1, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-55, bitscore: 175.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.4e-11, bitscore:
                     30.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MCSELPEYRFPESRFERRGAPRNMKCNPMIDVDAFDHKFFGVTSR
                     EAKFMDPQQRLALQVAYQALESAGYFGRDAKDKGKDMGCYIAACSNEYHENVISHPPSA
                     FSLTGSIRPFTAGKVSHYFASGTAIHQACRAVATGEYPSAVAGATNIFVSPESFQDLAH
                     GGFISKTGQSKSFDAAGDGYCRGEGVAFIVLKKLSAALRDGDPVKGVITATAINQNANG
                     GSITVPHGPSQMKLYRKALKFANLAPGDISYVEAHGTGTAIGDPIEVNSIQGVFSNPHY
                     QSDKRKTYLGSLKSNIGHTEASAGISGLIEVLLMMQREVIPQQALFHNLSPAIAPLESD
                     GIEIPKKNVPWNSQRKVVCVNNYGASGTNVVMIVTQPPQFSKSLKIVPAIDFPISITAF
                     SSSSLASYCSALLEFISQSVNKDLLGDLAYHLFLRKNTSLPYSINATVSSLPELKNLLE
                     GTILQEPSTIEKSPRPVVLLFGGLTGKTASVPRVFYDSFLVFRKHLDECDTQLQAIGAP
                     SIFPAIFEPGTHSDMILDHCILFSSQYASAVSWLDCGMRPVRTIGHSFGQMTALCVSGV
                     LSLHDALRLVVTRANLISSRWGKDPGLMIAIEAGPYKASELMAQHAHLNLKVSCYNGPQ
                     SLILGGSTASVDAFEAWLKSSAEAIRFKRLEIPNAFHTALTDPLVDSLLHIAKQLHIRQ
                     SKIKVETCSQHKAWQAVTSSLLASHVRDPVYFHEAVSRITEELGPCTWVETGSASAAPM
                     LRRALGTEAASHDIKAMKLDCTSSLKPLADLNTELWRLHLPVQFLPFHQSHQHQYGALN
                     LPPYQFDKSRHWLEWKAPASPAVVAQEPVLEEVPLLRVIQMTTKGGEFKINTRHKRWQA
                     VCSEHRILDVSVCPLSSLTDMILEALNKTQRTSKQQASTYRLEHLALLRPIVTQLEDEI
                     TLTLSSADQPQSWTFTIGSASHSTSQRYASGTVRTSTMETGVDFARLQRLVNFSRIQKL
                     TADAEADSLTADAEADSAKGKTVYRSLAELYQIPKSMQKNREVSAKGKEAAAYLTLSSR
                     SRLPSDKDFSCAVYVKFFESQGSEIARDVFAFDIGSRLLSVVMLDVSFNKVPIGTLRQA
                     LVSTTAPLQPSVSCTSAAVEISEPAVPPSDPSWTPASILEDTVSPNPSGLPDLVEALCH
                     LLAHVADVDPNVIHKNTTFEDLSIDSLMIIEITEAINKTFAVNLTMNDIVIVDGFDSLC
                     TMIAQDTRSFYYKPEAGLQRHSDSSDSDGLSTNPETAVTSTTEASNDEEGDELADRCLK
                     EAFESLEIVCGEFNVFAKQTGCDKFWSQVYPPQVNLVVAYIAEAFHKLGLDLFTIETGQ
                     KIPTVSHIPKYDKLLHQLMLALRDDGLISRTGSGWTRTSKPLSVHPSSQRFHQILDDFP
                     QFHIEHKLLQTVGPHLEACLTGEVDPLSLLFGSPEKRKLMADQYSLSPLLAAGSQHLAS
                     FIRKAFASRASRQKKRPVSAAAAVRVLEIGGGTCGTSLHATRALAELGVPVEYTFTDIS
                     SSFVTAAKSKLTEHKFVRYRTLDITADPPSELRGCFDLIIVTNVIHATPDIRKSLGNAR
                     QMLAPGGVLALMECTRNLYYFDLIFGLLDGWWAFTDGREHALIDDGKWKEAFTRAGFER
                     VDWTGAEGETLRIIVAG"
     aSDomain        join(1244..1598,1642..2402)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_10603_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.30E-111"
                     /label="10603_PKS_KS.1"
                     /locus_tag="10603"
                     /protein_end="377"
                     /protein_start="5"
                     /score="363.7"
                     /tool="antismash"
                     /translation="PEYRFPESRFERRGAPRNMKCNPMIDVDAFDHKFFGVTSREAKFM
                     DPQQRLALQVAYQALESAGYFGRDAKDKGKDMGCYIAACSNEYHENVISHPPSAFSLTG
                     SIRPFTAGKVSHYFASGTAIHQACRAVATGEYPSAVAGATNIFVSPESFQDLAHGGFIS
                     KTGQSKSFDAAGDGYCRGEGVAFIVLKKLSAALRDGDPVKGVITATAINQNANGGSITV
                     PHGPSQMKLYRKALKFANLAPGDISYVEAHGTGTAIGDPIEVNSIQGVFSNPHYQSDKR
                     KTYLGSLKSNIGHTEASAGISGLIEVLLMMQREVIPQQALFHNLSPAIAPLESDGIEIP
                     KKNVPWNSQRKVVCVNNYGASGTNVVMIVTQP"
     aSModule        1244..5042
                     /complete
                     /domains="nrpspksdomains_10603_PKS_KS.1"
                     /domains="nrpspksdomains_10603_PKS_AT.1"
                     /domains="nrpspksdomains_10603_PKS_DH.1"
                     /domains="nrpspksdomains_10603_PP-binding.1"
                     /iterative
                     /locus_tags="10603"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1797..1835
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_10603_0001"
                     /evalue="4.40E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="10603"
                     /protein_end="188"
                     /protein_start="175"
                     /score="13.3"
                     /tool="antismash"
                     /translation="FDAAGDGYCRGEG"
     CDS_motif       2028..2075
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_10603_0002"
                     /evalue="1.20E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="10603"
                     /protein_end="268"
                     /protein_start="252"
                     /score="14.0"
                     /tool="antismash"
                     /translation="YVEAHGTGTAIGDPIE"
     CDS_motif       2142..2186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_10603_0003"
                     /evalue="2.80E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="10603"
                     /protein_end="305"
                     /protein_start="290"
                     /score="10.4"
                     /tool="antismash"
                     /translation="GSLKSNIGHTEASAG"
     aSDomain        2706..3551
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_10603_PKS_AT.1"
                     /evalue="4.20E-54"
                     /label="10603_PKS_AT.1"
                     /locus_tag="10603"
                     /protein_end="760"
                     /protein_start="478"
                     /score="175.8"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mxmal"
                     /tool="antismash"
                     /translation="FGGLTGKTASVPRVFYDSFLVFRKHLDECDTQLQAIGAPSIFPAI
                     FEPGTHSDMILDHCILFSSQYASAVSWLDCGMRPVRTIGHSFGQMTALCVSGVLSLHDA
                     LRLVVTRANLISSRWGKDPGLMIAIEAGPYKASELMAQHAHLNLKVSCYNGPQSLILGG
                     STASVDAFEAWLKSSAEAIRFKRLEIPNAFHTALTDPLVDSLLHIAKQLHIRQSKIKVE
                     TCSQHKAWQAVTSSLLASHVRDPVYFHEAVSRITEELGPCTWVETGSASAAPMLRRALG
                     T"
     CDS_motif       2931..3050
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_10603_0004"
                     /evalue="6.30E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="10603"
                     /protein_end="593"
                     /protein_start="553"
                     /score="50.4"
                     /tool="antismash"
                     /translation="GMRPVRTIGHSFGQMTALCVSGVLSLHDALRLVVTRANLI"
     aSDomain        3870..4226
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_10603_PKS_DH.1"
                     /evalue="1.10E-08"
                     /label="10603_PKS_DH.1"
                     /locus_tag="10603"
                     /protein_end="985"
                     /protein_start="866"
                     /score="27.5"
                     /tool="antismash"
                     /translation="KRWQAVCSEHRILDVSVCPLSSLTDMILEALNKTQRTSKQQASTY
                     RLEHLALLRPIVTQLEDEITLTLSSADQPQSWTFTIGSASHSTSQRYASGTVRTSTMET
                     GVDFARLQRLVNFSR"
     CDS_motif       4146..4166
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_10603_0005"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m4"
                     /locus_tag="10603"
                     /protein_end="965"
                     /protein_start="958"
                     /score="-3.4"
                     /tool="antismash"
                     /translation="ASGTVRT"
     aSDomain        4884..5042
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_10603_PP-binding.1"
                     /evalue="1.20E-09"
                     /label="10603_PP-binding.1"
                     /locus_tag="10603"
                     /protein_end="1215"
                     /protein_start="1162"
                     /score="30.4"
                     /tool="antismash"
                     /translation="ALCHLLAHVADVDPNVIHKNTTFEDLSIDSLMIIEITEAINKTFA
                     VNLTMNDI"
     aSDomain        5805..6323
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_10603_cMT.1"
                     /evalue="4.80E-56"
                     /label="10603_cMT.1"
                     /locus_tag="10603"
                     /protein_end="1642"
                     /protein_start="1469"
                     /score="181.4"
                     /tool="antismash"
                     /translation="RASRQKKRPVSAAAAVRVLEIGGGTCGTSLHATRALAELGVPVEY
                     TFTDISSSFVTAAKSKLTEHKFVRYRTLDITADPPSELRGCFDLIIVTNVIHATPDIRK
                     SLGNARQMLAPGGVLALMECTRNLYYFDLIFGLLDGWWAFTDGREHALIDDGKWKEAFT
                     RAGFERVDWT"
     CDS             complement(8406..9092)
                     /locus_tag="10604"
                     /transl_table=1
                     /translation="MAYLQRQGNEAAKLNKLLELRSTGFSPKIGSFRSSMEHSSDSKSS
                     HSLAPLKSISESGSSESSKSLRSDHSRFSTHQGPSQEPNIVHFVFKSLEARYQPSWASV
                     ASAAKYADFRRSAGIVSHPFKEGVGVILWGQGKAIMSVIQRGRAQMLTKVSRLAKQNSV
                     RGKAIIFASRQREPLDAEVDAAMQTLKSLGATALEPIHHYRVGSQAMMLLHGKDALPDI
                     YIEARF"
ORIGIN
        1 ctgggtgcca cgctgtgccg gccgagggga taaatgcttt gccacctggg tattaccatc
       61 ttttgatcaa tcggaggccg tatccgcctg gataagcaac attgcattag ctgaaagttg
      121 tcttacaaag gaagtcgagc ctgctcacca caacttcagc catactcccg actacaatca
      181 tagttagcca ctcaactaca ataatattcg gcactaatta gccactcgcg cgcggcgtcg
      241 aagatgtcac ggtgttgagc attttgtatc tatgcaccta ctaggtcctg ctgcagtacc
      301 acttgctgta cgggaaggca caatctcgtt tacaatcgaa gcctgctcca ttgacagatt
      361 gttgttcggc tagaccccgc gactgaacaa catccggcca acgtcgtgga cactgctctg
      421 tccaaaggtt agacgtttga tgaattgcag gctcttcact catcgacctg catctgtctg
      481 cactagacca ggtgcaacat ggacccaaac tcacctggcc tatccaaccg agttcgggcc
      541 ttgttgtagg ctggctaaat aatttctcag gcgatctgga caatttaata gctcatcaat
      601 tgggcatgac tgattaagct ttcctgatca atgaccccgt attccttggc aagatgcaac
      661 cgaactgaac aactcttttg atcgagtgga gatgtgttat ttgcctccga aggaaaaaca
      721 aatcgctgtg tggttcgtgg tacggcttat cgactatagt attaagacga ttgaacaatg
      781 gctagacagt ggatcatgcg atacggagcg gactcgcggc aattatattc ttctctcaaa
      841 catagtgtcc tactcttcga gaatctctgg ctcaaagaag tccgttccca taaaatccgc
      901 ccactcgtcc aagaacgcat tccccagggt ttttgagtgt agtggctcct cagtagaatc
      961 aggatggctg aggacgtgac ggcacagact gatgggtcgt cgaaagctca agaatctgac
     1021 aatgcaccaa atatcatatg cccactactg gatgggtttg atcctttatc gtcctcagac
     1081 tttgcagttg ctgtcatagg catggcatgc aagtttcccg gtgcagagtc gctggcacaa
     1141 ttatggcaca tcctcgaaac tgggacttca atgtcccggt gcagagtcgc tggcacaatt
     1201 atggcacatc ctcgaaactg ggacttcaat gtgcagcgag cttccagaat accgttttcc
     1261 ggaatctcgc ttcgaacgaa ggggtgctcc cagaaatatg aaatgtaacc ctatgatcga
     1321 cgtggacgcc tttgatcata agttctttgg agtgacgagt cgagaggcaa aatttatgga
     1381 tccccagcag agactcgccc tgcaagttgc atatcaagct ttggagtctg ctggctactt
     1441 tggtcgtgat gctaaagaca aaggaaagga tatgggttgc tacatcgcag cttgcagcaa
     1501 tgagtatcat gagaacgtaa tctctcatcc tccttctgca ttctccctaa ccggatctat
     1561 acgaccattc actgcgggca aggtgagtca ctactttggt tggacgggcc ctgttatcat
     1621 gtacgacacc gacgtgtgca gcatcgggga ccgccataca tcaagcctgc cgtgctgttg
     1681 ctacaggaga atatccttct gcagttgcag gggctacgaa tatcttcgtc agcccggaga
     1741 gttttcagga cctcgctcac ggtggcttca tcagcaagac cgggcagtca aagtcatttg
     1801 acgctgcagg cgacggctac tgccggggtg agggtgtagc tttcattgtc ctcaagaaac
     1861 tctccgccgc attgcgggat ggcgatcctg tcaagggagt cattactgct actgccatca
     1921 accaaaatgc taatggcggc tccatcaccg tgcctcacgg accttctcag atgaagctct
     1981 atcgcaaagc gctcaaattt gccaatctcg ctcccggaga tatctcctat gttgaagctc
     2041 atgggaccgg cacagctata ggggatccta ttgaagtgaa cagcattcaa ggagtattca
     2101 gcaatccgca ttaccagagc gacaagagaa aaacctatct aggatcgctc aagagcaaca
     2161 ttgggcatac cgaagccagt gccggaatct ccggattaat cgaggtcttg ctgatgatgc
     2221 aaagggaagt gattccacaa caggctctat tccacaatct cagtccagcc attgcgcctt
     2281 tagagtcaga cggtatcgaa atacctaaaa agaacgtccc atggaattct caacgcaagg
     2341 tcgtctgtgt gaacaactat ggagcatcgg gaacgaatgt agtaatgatt gtcactcagc
     2401 caccgcagtt ttccaaatca ttgaagattg tgccggctat agattttccg atctcaatta
     2461 cagcctttag ctcctcgagt ctagcatcgt attgttctgc tctcctggag tttataagtc
     2521 aatcggtgaa caaagatctg ctgggggacc tcgcctacca cctcttcctc cgtaagaata
     2581 cgagtctacc ctactccata aatgcgactg tttcttcact tccggaactc aaaaatttgc
     2641 tcgagggcac tatattacaa gagccctcga caattgagaa aagcccacga ccagtggtac
     2701 tgctctttgg tggactgacg ggcaagacag ccagtgttcc tcgagtcttt tacgactctt
     2761 ttcttgtctt taggaagcac ctcgacgagt gcgatacaca gctgcaagcg attggggctc
     2821 caagcatctt cccagcaatc tttgagccag gcacgcacag cgatatgatt cttgatcatt
     2881 gcatactgtt tagtagtcag tacgcgagcg ccgtgtcgtg gctggattgt ggaatgcggc
     2941 cagtaaggac aataggacac agctttggtc agatgactgc tctatgcgta tctggagttc
     3001 tgtcgcttca tgatgcgttg cgactggtag tcacgcgtgc caatttaatt agttctcgat
     3061 ggggtaaaga tcctgggctg atgattgcaa ttgaggcagg tccgtataag gcatcggaat
     3121 tgatggcaca acacgcccat ctgaatctaa aagtttcttg ttacaacggc ccgcagagcc
     3181 ttatacttgg cggaagcacg gcatccgtgg atgcctttga agcctggcta aaatcctccg
     3241 cagaagcaat acggttcaaa agattggaga ttccgaatgc tttccatacc gccttaacgg
     3301 atcctctggt tgattccctg ctgcatattg cgaaacagct tcacattcga caatccaaaa
     3361 tcaaagtcga gacttgttcc cagcacaagg catggcaagc ggtcacctca agccttcttg
     3421 cgtcgcatgt gcgagatccg gtatacttcc atgaggcagt gagtaggatc acagaggaac
     3481 tcggcccttg cacgtgggtc gagacaggct ccgcatcggc cgcgccaatg ctgcgacgag
     3541 ctctcggaac ggaggcagca tctcacgata tcaaggccat gaagctcgat tgcacctcct
     3601 ccctcaagcc cttggctgat ctaaacactg agctttggag gctacacctt ccagtacaat
     3661 tcttgccctt ccaccaaagc catcagcatc aatatggggc tttgaatctc cctccatatc
     3721 aatttgacaa gtcacggcat tggctcgagt ggaaagcccc cgcttcacca gcagtcgttg
     3781 cccaagagcc agtcttggag gaggtcccgc tcctacgggt catccagatg accacaaaag
     3841 gaggagagtt caaaatcaac actcgacaca agagatggca agctgtttgc tctgagcacc
     3901 gcatacttga cgtctctgtc tgccccttat cttccctgac agatatgatc ctcgaggctc
     3961 ttaataagac tcagagaacc tcaaagcaac aggccagtac ttataggttg gaacatctgg
     4021 cgttgctgcg gccgatcgtg actcagctcg aggacgaaat caccctgact ttatcgagtg
     4081 cagaccaacc acagtcatgg acattcacta tcggcagcgc ttcccactcg acaagtcaaa
     4141 gatacgcctc tggtaccgtc cgtacgagta ccatggagac cggggtggat tttgctcgct
     4201 tacagagact cgtcaatttt tcccgcattc aaaaacttac agctgacgct gaagctgatt
     4261 cgcttacagc tgacgctgaa gctgattcgg cgaaaggaaa aactgtatac agaagcctcg
     4321 cggaactcta ccagataccc aagtctatgc aaaaaaacag ggaagtatcc gccaagggca
     4381 aagaagcagc cgcctacttg acactttcgt ccaggagccg gttcgagttc attgatcttc
     4441 taatccaagt tcccctcctt tgcttgaatt gcctatagga tcatctagac ggggagatat
     4501 acatccattc aagtattgga caagtagatg ataaggtcta ttccagcctc ccgtccgaca
     4561 aggatttttc ctgcgctgtg tacgtcaagt ttttcgagtc acaaggttcg gaaatcgctc
     4621 gtgatgtttt tgcctttgat ataggaagca ggctactgtc tgtcgtgatg ttagatgtgt
     4681 cctttaacaa agtaccaatt gggacactcc gacaggctct tgtcagtact actgctcccc
     4741 ttcagcccag cgtgagctgc acgtcggccg ctgttgagat ttctgagcca gccgtgccgc
     4801 cttcagatcc ttcatggact ccagcatcga tcttggaaga tactgtatcc ccgaacccca
     4861 gcggcttacc agaccttgta gaggctctgt gccatctact tgcgcatgtt gcagacgtgg
     4921 atcctaatgt aattcacaag aacaccacat tcgaggatct cagcatcgat tcattaatga
     4981 tcattgaaat cacagaagcg atcaacaaaa ccttcgccgt taatcttacg atgaacgaca
     5041 tcgtaatcgt agacggcttc gactcgttgt gcacaatgat agcgcaggat accagaagct
     5101 tctactataa gccagaagct ggtttacaaa ggcattcaga tagctctgat agcgacggtc
     5161 tcagtacaaa ccctgagaca gctgtcacct ctaccaccga ggcctcgaac gacgaagaag
     5221 gcgatgagtt ggccgataga tgcttgaagg aagccttcga atctctggag attgtatgtg
     5281 gggaattcaa cgtttttgcg aaacaaacag gctgcgacaa attctggtcc caagtctatc
     5341 ccccgcaggt aaatctagtt gttgcataca ttgccgaagc attccacaag ctaggccttg
     5401 acctctttac aatcgagaca ggccagaaaa ttccgaccgt atcccacata cccaagtacg
     5461 ataaactact ccatcagcta atgcttgccc ttcgcgacga cggcctcata agccgcaccg
     5521 gcagcggttg gacacgcacc tcgaaaccac tatctgtcca cccgtcctcc cagagattcc
     5581 accagatcct agacgacttc cctcagtttc acatagagca caagctactc caaaccgtcg
     5641 gtccccacct cgaagcctgc ctcaccggcg aagtcgaccc tctctcccta ctcttcggta
     5701 gcccagaaaa gcgcaaactg atggcagacc agtactcact ctctccgctc ctagctgcag
     5761 gctcgcagca cctcgccagc ttcatccgca aagccttcgc ctcccgcgcg agcaggcaga
     5821 agaaaagacc cgtctccgct gctgccgccg ttcgcgtcct cgaaatcgga ggtggcacct
     5881 gcggcacctc tctgcacgct accagagcgc tcgccgagct cggagtgccg gtcgaataca
     5941 ccttcacgga tatctcatcg agcttcgtga ccgccgccaa gagcaagcta acggagcaca
     6001 agttcgtcag gtaccgcacg ctggatatca cagcggatcc gccttcagag ctgcggggtt
     6061 gcttcgactt gatcatcgtc accaacgtga ttcacgccac gccagacata cgcaagagcc
     6121 tgggcaatgc gcgccagatg ctggcgccgg gtggggtgct ggcgctcatg gagtgcacgc
     6181 ggaacttgta ctatttcgat ctcatctttg ggctgctgga tgggtggtgg gcgtttactg
     6241 atgggagaga gcatgcgcta atagatgatg gcaagtggaa ggaggcattt acccgcgccg
     6301 ggttcgagag agtagattgg acgggggccg aaggggagac gctgaggatt attgttgctg
     6361 gatgaggaac agcactgcat ggactgtgct gcgtactatt ttttgtatga atgttgggtt
     6421 gagatagact gtgcttgctt gcccatttat ctctgggcca tcgccaagtc tatggtacat
     6481 aggatatcta gatcagtgct ttcacgcgtt cctagccata ttctatgcct ctgggacttg
     6541 caaatcagag gcagcttgcc cgggctcctg ggctcaaaat ggaagaaacg tagatatcag
     6601 agtttgagcg agacggttaa tggcacgtga tattctaacg tagattacgt gcaagtccac
     6661 ctgtgacaag gagaggaggc accgtgactg ctttctttgc acccttcatt gggaaagacg
     6721 ctagggctag attgagacca tggtggaagg atcatccgta cgtacagtgc gacttcaagt
     6781 tcacgatgac cttgcttcga ccgcgtgcgg agtcgcgtcg atcacgatct caactgtgct
     6841 gaggctctgt aagacgctaa agcaacctca tgaagcaaca ctcggaatgt atgtgtcaaa
     6901 aaggcatcat cagcttttgg agacagagta tacttgatct acgatttctt tacgctctag
     6961 acgttttgtc taaagaattg cttagctcca gatgggaagt gatatggatc gattgacact
     7021 atacaagggc gtattggagc tgctcccgga tatcgccaaa ggaatagtag gcacgcgttg
     7081 agaagggaca gcaagacgca acgcattgtt cgtgcaattt tcttgatttc ccatacgtag
     7141 gcaccacgct tcacaacacc atgatagaag tcgtaccaga aagtcaatgc cgcaagccca
     7201 ggaccagcga attgagccac agggcaaaaa gtagagacga agtatcatgc catatgccgc
     7261 gttgagtacg acttcggcta cagcctactc gaggctctgc aagaccccat tttaacggtg
     7321 cctgtggagc tctaaactga gatcgactgc tccagttgca tgagcgaaat tgaagggcca
     7381 agatgttctg gattgttggc taattaacac cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7441 nnnctcgatc tgatctcgat ctgattgagc cagaggagct caaatctctc ctgagatcac
     7501 ctgtgtggtg aatggttcgc aatcgcagtt gtctaattct tacatacggc tgaagccgat
     7561 agcacccttt actcggaagg tgctacgcat ctactgcgtc gcctaggaag ccatcgatat
     7621 ggttcaaatt ccgagctgac ctatgcagta gcgtcaagca aggtgcctcg gacactctca
     7681 gcaaaactta cccaggcttg tttgctccct ttgccaccta gatgtagagg gtcgttatca
     7741 gccaccggtt tgtatcgcgt taacgtgctt gtagtcaagt gtaacgctta gctagagacc
     7801 gcacgaacga agtgactcgt ggcaaggttc aggttgatat gtgggcgacg aaattttggg
     7861 acactaccat atgctcacgc ttgatcgatc atccgaattc tcccctcggt catggcggta
     7921 aattgatcat tgaccatggt ccttgatcca gaacattcat ttacggcaca attgtaacca
     7981 gttgtagtca cacactgaac catagcaaag ggctttttga gagaccgcat cgcgatgaaa
     8041 ttcaacagga taggaacatc gctcaatatc agtacttgaa ttcctattcc catcataaaa
     8101 attggtagag gggagacttg attgcggatg aacttcactg ctactaactt tgcatgggga
     8161 ttgtccccgt caactaattg actggtgtag gggcaggatc agcgcctgca cctgcgaggc
     8221 acagcttctt tcgggcaaat atggttgcgc ccatctcgtc cacttttcga agatgatcgt
     8281 tttaccagaa gggcgggggt accgaaatag gctgggatac tgcatagaga gaataggaat
     8341 gaagccatgt ctgaagtaat atcgcagtag caacaacctc gagcctaggt ccttcgggtg
     8401 tgaagctaga atctagcctc gatataaata tcagggagcg catccttccc atgtaggagc
     8461 atcattgcct gactacccac gcgatagtgg tgtatcggct ccaaagccgt ggccccaagg
     8521 cttttgagcg tctgcatggc cgcgtcaact tcagcgtcta acggttccct ctgtctcgac
     8581 gcaaagataa ttgccttgcc tctgactgag ttttgtttcg cgagtcgcga cactttagtc
     8641 aacatttgcg cccttcctct ttggataact gacattatgg cttttccctg tccccagaga
     8701 atcacaccga ctccctcttt gaagggatga gacacaatgc cggcagacct cctgaaatct
     8761 gcgtatttcg cagcggaggc aacactagcc caacttggtt gatagcgagc ttcgaggctt
     8821 ttgaagacga agtgcacgat gttcggttct tgtgagggtc cttggtgggt cgagaaacgg
     8881 ctatgatctg atcgtagact cttggaagac tcagaggaac cactttcgct gatgcttttc
     8941 aacggagcaa ggctgtgaga ggacttgctg tctgatgaat gctccatgga agacctaaag
     9001 gagccgattt tggggctaaa gcctgtggat cgtagctcga gtaacttgtt aagtttcgcg
     9061 gcttcgtttc cttgacgttg caaatatgcc atggagagct ctgcgctggc gagagagtct
     9121 ctttcgtgaa ccaaaatatt gtctatagtt ccgccgagac tcgcgctctc tcattcttcg
     9181 actgtctcct aattagctag gcctgttaag gacggagtaa gttgtttacc gatcggacgc
     9241 ttctccaatc gtcattaatg tgtttacagt gcagtaaaca acaagtccgt ataggaagtt
     9301 catgactcaa aacactgata cacgacagaa tgagtcgaga cttaaaacgt gtggaatggg
     9361 gagaaaatga gagattgtaa agagatctag gaatgtcttt catgcttgag aagaaagcca
     9421 tcacacctgc ttgttttaaa gtcgacaaac caaaccttga tctcagatcg tggacggaga
     9481 gcaagcacag atcttgctgt gtgctcaaag aaacttgaaa acatgctgga cataaacgtg
     9541 tgggaatatt gatgagaagg tcttacccta gagccttttc tccgaatagg cacatattgt
     9601 ggctcatcca ccaccattcg attttcgtct cggaacatat ctgttgtact ctaagcgcag
     9661 caatgaaaca gaggcagtat gccagacaca cccgcgcgcc tgtcccacga cgttgtctta
     9721 tcttgatata gatgggggga cgtgtcttca aggcgatccg ctaaatcagt attgagcatt
     9781 gacgcaagaa caaacgaatt gaggcactag actactgaag cactccctag gccatataaa
     9841 tgataggtat gaggtgtgct ccgattagat agtgtctcaa ttattttgtc atccg
//
