LOCUS       scaffold_973           13354 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  .
ACCESSION   scaffold_973
VERSION     scaffold_973
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2025-04-15 23:30:40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13354
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13354
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[646:5716]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="30000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      647..5716
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="30000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..13354
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13354
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     CDS             complement(join(647..877,932..2364,2425..2665,2716..3072,
                     3152..3679,4014..4159,4433..4556,4622,4764..5114,
                     5178..5716))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (18-350). E-value:
                     8.9e-91. Score: 296.7. Matches aSDomain:
                     nrpspksdomains_4054895_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (434-670). E-value: 2.2e-63.
                     Score: 206.2. Matches aSDomain:
                     nrpspksdomains_4054895_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (718-863). E-value: 1.2e-16.
                     Score: 53.4. Matches aSDomain:
                     nrpspksdomains_4054895_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1149-1270). E-value: 6.2e-57.
                     Score: 184.3. Matches aSDomain:
                     nrpspksdomains_4054895_cMT.1"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 97.6; E-value:
                     1.4e-29)"
                     /gene_kind="biosynthetic"
                     /locus_tag="4054895"
                     /sec_met_domain="mod_KS (E-value: 1.8e-74, bitscore: 239.1,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 3.9e-72, bitscore: 231.4,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.2e-102, bitscore:
                     331.9, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 3.5e-74, bitscore: 238.2,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 6.3e-92, bitscore: 296.7,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.6e-64, bitscore: 206.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MNGIQKVPHVTRDAEQVPVAICGMGMRLPGGIHNDRALYDFLINK
                     GDARSTIPEDRYNIDAYYSAHSKHGTISTKHGYFMNDVDFSKFDLSMFTLTPAEAEQVD
                     PNHRLVLEVVREAFESSGETEWRGKNIGTYVGMFSEDWQDLQHKDTHEYNPYRVLGGLD
                     FALPNRISYEYDLKGPSMIIKSACSSAGLGLHQALQAIRLGEISAAIVCGTSLILAPGM
                     TISMSVKMALSPEGSSKSFDASADGYARGESVTALYIKSLDEAIRDKNPIRAIIRSSAS
                     NADGRTNGMAMPNPEAIKPNLGHSEGAAAITSIIKAVLSLENRTIIPNIKFENPNPGNS
                     ASTPTIKQQKRRKILLFFSANHPESLKRVAENIKGYFRKHPDRLDDLVLSNQWIEFFSV
                     WNTHRHGRSKVKLLELPESHPTYNEIYALLNWDDKSILGKAEYSQPICTALQIALVDLL
                     AMWSITPSAVVGHSSGEIAASYAAGALTMKEAIIAAYYRGYVCKSPQRTGGMAAIGMGK
                     EEVSSYLVRGVRIACENSTSSVTLSGDLNILENIMSTIGEIMPDVLIDHMTIVGDLYCK
                     LITPHLSPRTPKIPFYSSVTPIGLHEASDFGPRYWQDNLESPVMFHSAVRALLAGSKKC
                     SVHLEVGPHAALSGPLRQIYNETSIPINYVSTLIRGKDDADSFLERSNTQVLTDLPSYP
                     WHYERSYWSETRIMKNWRFRKHGPHDLLGLRTLEGGDISPTWRIELRLVDVPWLKDHCV
                     GSDVVFPGAVKDVELSKAMVLYNDKTIEIVTSLQPPRLTSTLDSDWYEFQIISYNGAAW
                     NRHCSGLVRSGPTSVILPWRTQTLDRQVSSSRWYKTMSRVGLNYGPRFTGLENIAASVL
                     ENTATAVVFDKQDVSESLYMIHPSTLDLAFQSLTVASCRGIYRAFRSLFLPTFIEELYV
                     GNVTGKKVHIKTIAAGKPGAIQGNLYGISESAMVFYLKGFRGKAVEDSGMEKLPELKTL
                     QLQWKPHFQFLDAGDLMKLKYDIREQVQDLEKLYVLCAVESRNALSGIPTTQPHLEKYW
                     GWLDQQFERFQQPGYPLVEELMELARLDKSERRQLISTTLDHCKASGGWGPATAIWRAY
                     DQVVNVFEGRTDYLDLLLQDGVLTGIYSWCNDIWEFTDFMQLLGHTQPQMRILEIGAGT
                     GGLTAKFLEQLKSDFGERLYLKYTFTDISSGFFVQAKERFKDYVGIEYKTLDVSKNPLE
                     QGFAAGEYDLIIASNVLHATPFLHDTLTNVRTLLQPKGQLFLQELCPSEYIVFTRYANL
                     LTSNKSDELHNGRPSMTTLLFRLFLLSPVFFM"
     aSDomain        complement(join(788..877,932..1204))
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4054895_cMT.1"
                     /evalue="6.20E-57"
                     /label="4054895_cMT.1"
                     /locus_tag="4054895"
                     /protein_end="1270"
                     /protein_start="1149"
                     /score="184.3"
                     /tool="antismash"
                     /translation="LGHTQPQMRILEIGAGTGGLTAKFLEQLKSDFGERLYLKYTFTDI
                     SSGFFVQAKERFKDYVGIEYKTLDVSKNPLEQGFAAGEYDLIIASNVLHATPFLHDTLT
                     NVRTLLQPKGQLFLQEL"
     aSModule        complement(788..5662)
                     /domains="nrpspksdomains_4054895_PKS_KS.1"
                     /domains="nrpspksdomains_4054895_PKS_AT.1"
                     /domains="nrpspksdomains_4054895_PKS_DH.1"
                     /domains="nrpspksdomains_4054895_cMT.1"
                     /incomplete
                     /iterative
                     /locus_tags="4054895"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(2063..2364,2425..2557))
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4054895_PKS_DH.1"
                     /evalue="1.20E-16"
                     /label="4054895_PKS_DH.1"
                     /locus_tag="4054895"
                     /protein_end="863"
                     /protein_start="718"
                     /score="53.4"
                     /tool="antismash"
                     /translation="HDLLGLRTLEGGDISPTWRIELRLVDVPWLKDHCVGSDVVFPGAV
                     KDVELSKAMVLYNDKTIEIVTSLQPPRLTSTLDSDWYEFQIISYNGAAWNRHCSGLVRS
                     GPTSVILPWRTQTLDRQVSSSRWYKTMSRVGLNYGPRFTGL"
     CDS_motif       complement(2426..2473)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4054895_0005"
                     /evalue="3.10E-07"
                     /label="PKSI-DH_m2"
                     /locus_tag="4054895"
                     /protein_end="762"
                     /protein_start="746"
                     /score="22.9"
                     /tool="antismash"
                     /translation="WLKDHCVGSDVVFPGA"
     aSDomain        complement(join(2752..3072,3152..3538))
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4054895_PKS_AT.1"
                     /evalue="2.20E-63"
                     /label="4054895_PKS_AT.1"
                     /locus_tag="4054895"
                     /protein_end="670"
                     /protein_start="434"
                     /score="206.2"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="SILGKAEYSQPICTALQIALVDLLAMWSITPSAVVGHSSGEIAAS
                     YAAGALTMKEAIIAAYYRGYVCKSPQRTGGMAAIGMGKEEVSSYLVRGVRIACENSTSS
                     VTLSGDLNILENIMSTIGEIMPDVLIDHMTIVGDLYCKLITPHLSPRTPKIPFYSSVTP
                     IGLHEASDFGPRYWQDNLESPVMFHSAVRALLAGSKKCSVHLEVGPHAALSGPLRQIYN
                     ETSIPINYVSTLIR"
     CDS_motif       complement(3368..3454)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4054895_0004"
                     /evalue="5.60E-11"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="4054895"
                     /protein_end="491"
                     /protein_start="462"
                     /score="34.8"
                     /tool="antismash"
                     /translation="ITPSAVVGHSSGEIAASYAAGALTMKEAI"
     aSDomain        complement(join(4125..4159,4433..4556,4622,4764..5114,
                     5178..5662))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4054895_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="8.90E-91"
                     /label="4054895_PKS_KS.1"
                     /locus_tag="4054895"
                     /protein_end="350"
                     /protein_start="18"
                     /score="296.7"
                     /tool="antismash"
                     /translation="VAICGMGMRLPGGIHNDRALYDFLINKGDARSTIPEDRYNIDAYY
                     SAHSKHGTISTKHGYFMNDVDFSKFDLSMFTLTPAEAEQVDPNHRLVLEVVREAFESSG
                     ETEWRGKNIGTYVGMFSEDWQDLQHKDTHEYNPYRVLGGLDFALPNRISYEYDLKGPSM
                     IIKSACSSAGLGLHQALQAIRLGEISAAIVCGTSLILAPGMTISMSVKMALSPEGSSKS
                     FDASADGYARGESVTALYIKSLDEAIRDKNPIRAIIRSSASNADGRTNGMAMPNPEAIK
                     PNLGHSEGAAAITSIIKAVLSLENRTIIPNIKFENPNPGNSASTPTIKQQK"
     CDS_motif       complement(4479..4544)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4054895_0003"
                     /evalue="1.20E+00"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="4054895"
                     /protein_end="323"
                     /protein_start="301"
                     /score="2.4"
                     /tool="antismash"
                     /translation="LGHSEGAAAITSIIKAVLSLEN"
     CDS_motif       complement(4898..4933)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4054895_0002"
                     /evalue="6.50E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="4054895"
                     /protein_end="252"
                     /protein_start="240"
                     /score="12.8"
                     /tool="antismash"
                     /translation="FDASADGYARGE"
     CDS_motif       complement(join(5084..5114,5178..5185))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4054895_0001"
                     /evalue="3.60E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="4054895"
                     /protein_end="190"
                     /protein_start="177"
                     /score="10.1"
                     /tool="antismash"
                     /translation="GPSMIIKSACSSA"
     CDS             complement(5895..6173)
                     /locus_tag="3805505"
                     /transl_table=1
                     /translation="MNEAMFLIKYPCLSMLFSLLLARVTIPLHRDQSEKQNALDSFHKA
                     NGSPNPVLLFSRQYKVGSRQTELAESNYLINLKSVYIDTSLRIIFGT"
     CDS             join(8251..8475,8529..8721,8784..8852,8906..9024,
                     9079..9565,9624..10063)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 116.5; E-value: 2.5e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="3805590"
                     /sec_met_domain="p450 (E-value: 2.8e-39, bitscore: 123.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSSKVHLEGLFLTFQSLLFFALPIAAFIVFAVLYAAHSNANPSVP
                     LYVPETSAAGNQKKRWMFDSVSLLQEAYKKFYGKPFRVWTTEGVQFVIPPDYVDELKML
                     LDHTFPSALRNVRPIEPSKLDYGHVVMKNDLNKNMGRVFPEVRDEVGVVFPLEFPECKD
                     WFPIQVYPKVLRLVSRVNGKIFVGNGLHQNEEWIKISCNYTRNVFLSSAKLRFFHPWLR
                     PIVQYFIPELRTVWKCNAKARELLAPIIQQRATQERNEDYKKPNDAIEWLRELIPELDK
                     NDPHFHGISQLGIGAVSVNTTSQLITNAIFNLATYPEYVPILKEEIDSVLEESGGEWTL
                     ESMGKLKKLDSFMKETLRYNGHLTATFQRKALRPITLSDGTYIPSGTFTFPPVNAISFD
                     PNIYPDANTFDGLRFYHLRQASLDDEKKYQLTSITKTQMQFGSGRHACPGRWFASHQIK
                     LVLAAMIDQYELKLKDGEGRPKSIVFQINQFPDPKAEIMFKNKKYGDQGGTD"
     CDS             complement(join(10375..10597,10649..10956))
                     /locus_tag="4039832"
                     /transl_table=1
                     /translation="MGDDAIRNRIALIRLHVEYTKAYERQSQNSHAKTIGRGCASVIID
                     AILESIHKEWKIFDNRRKSDLRVKFHDRKRYGKRWLLLTNALGPSVLLLCSTKMANMIH
                     NTTVTVKTLESIALKVKTDRVGTMRILQIMNPVARCLIDNDNGTGYDVDGVIKQLRNMI
                     PVTADGGENNETF"
ORIGIN
        1 tgactttaac ggtacgcagt acgtactggt aagagatttg tactatactg atagaagaat
       61 ttgtactaat agtccagata gtagccgata gattatggtt ccatgtacgc ttcgatacaa
      121 gttttgacct catatgttag tctacgccac tgaaaagtga ggataacagt ctacgcaaaa
      181 gttttgtatg aaactgttac tgcaaaaggg gataccagac gtatgataga ggcagagccc
      241 gagaatggcg attgagcgct gaattgtgct gtactaatag tacgtactgg tacacaaagc
      301 catgtactgg taagttttat gtaccaactg ttaaccacta agcttggacc agtttgtacc
      361 ggtaaggggt ctcataccaa ctatttttac catcaaaagc gttgttcact gtcgagagtg
      421 accgagtcgc accctgaaaa gcctgcgttc cgtagtctct tatcccattc ctctggtgtt
      481 atgaatgggc tgccgattcg accgtcctcc tcgctaagcc accagcaaga gaattgaccc
      541 tagaagacct agtcagatga ctgaagccag ccaatcggag aagtttcaca tgaaaacttc
      601 ggaaaaggtc aggatgaaag gcgggagggg gggggggaga agtgaatcac atgaagaata
      661 caggactaag aagaaataat cggaagagaa gagtagtcat tgaaggccta ccattatgaa
      721 gctcatcgct cttgttgctg gtcagtaaat tcgcataccg agtgaagaca atgtactcac
      781 ttggacacaa ctcttgtaag aagagctgac cttttggctg aagcaaggtc cgaacatttg
      841 tcaaagtatc gtgtagaaac ggagtcgcat gcagcacctg cccatatttt cagaagaagt
      901 gagtatagag agcaaggtca caattacata cgtttgacgc aatgatcagg tcgtattccc
      961 ccgcagcgaa cccctgttcc agtggattct tggatacatc gagggttttg tattcgattc
     1021 cgacataatc tttgaatcgt tcctttgctt gaacgaagaa tccggatgat atgtcggtga
     1081 acgtgtattt caggtacagc cgctccccaa agtccgactt gagctgctcc aggaatttgg
     1141 cggtcaaacc gccagttccg gcgccgatct ctagaatcct catttgcggc tgggtatgtc
     1201 ctagaagctg cataaagtcg gtgaattccc agatgtcatt gcaccaactg tagattccag
     1261 tgagaactcc atcttgaagc aggaggtcga ggtaatcggt tcgtccttcg aatacattca
     1321 ctacttgatc ataggctctc catatagcag ttgctggtcc ccaaccacct gaagctttgc
     1381 agtggtccag cgtcgttgaa ataagctgtc gacgttcgct tttatccaga cgagccaatt
     1441 ccattaactc ttcgactaac ggatatcctg gttgttggaa acgctcaaat tgttgatcca
     1501 accaacccca atacttctcc aagtgaggtt gtgtagtagg aataccagat agagcatttc
     1561 ttgactcgac tgcacacaga acgtataatt tctccaagtc ctggacctgt tctcgaatat
     1621 catacttcaa tttcatcaaa tccccggcat caaggaattg gaagtgcggt ttccattgta
     1681 attgaagcgt ttttagttct ggaagctttt ccatgcctga gtcttccaca gctttccctc
     1741 taaacccttt gagataaaac accattgcac tctctgagat accgtataag ttgccttgaa
     1801 tagcgccagg cttgccagcc gcaatggttt tgatgtggac cttctttcca gttacgttgc
     1861 caacatagag ttcctcgatg aaggtcggaa gaaataacga cctgaatgct ctgtaaattc
     1921 ctcgacaact tgccactgtc aaggattgaa aagcaagatc aagtgtggaa gggtgaatca
     1981 tatacagaga ctcggaaacg tcctgcttgt cgaagacaac ggctgtagca gtattctcaa
     2041 ggacgctggc agctatattt tccagtccgg tgaatctcgg tccgtagttc agaccaactc
     2101 gagacatggt cttataccac cgtgatgaag agacctgtct atcaagggtt tgagttctcc
     2161 atggtaggat cacagacgtg ggaccgctgc ggacaagtcc agagcaatgt ctattccaag
     2221 cggctccgtt atatgagatg atctgaaatt cataccaatc actgtccaac gtggaagtga
     2281 gtcttggtgg ttgcagactg gtaacaatct caatagtctt gtcattgtag agcaccatgg
     2341 ctttacttag ctctacatcc ttgactgtgt actctcgaat atcattgatt tggaaaatag
     2401 cttctcaggc catagcgatg taacctgctc cagggaacac aacatcgctt ccaacgcaat
     2461 gatccttgag ccaagggaca tcaacaagcc gtagttcaat tctccaagtg ggcgagatat
     2521 cacctccttc aagggtgcga agaccaagta ggtcgtgagg accatgtttt cgaaatctcc
     2581 agtttttcat gattctagtt tcagaccaat agcttctttc atagtgccaa ggataggatg
     2641 gaagatcagt gagtacttgc gtgttctcgg agacaaaggg gtaagagacc tggacaccaa
     2701 gtgaatgcag ctgaccgacc gctccaggaa cgagtctgca tcgtctttgc cgcgaataag
     2761 agtagaaaca tagttgattg gtattgaagt ctcgttgtaa atctgcctca aggggccgct
     2821 gagggctgcg tgaggtccaa cttctaaatg cacagaacat ttcttcgatc cagcgaggag
     2881 tgctcttaca gcagaatgaa acataactgg gctttccaag ttgtcctgcc aatacctagg
     2941 accaaagtcg gaagcttcat gaagccctat tggtgtgaca cttgaataga atgggatctt
     3001 gggcgtacga ggcgagaggt gtggcgttat gagtttgcag taaaggtccc cgacaatggt
     3061 catatgatct atctctatta gccgaaattt aattcgagtt gagacgaaac tcacgcgagt
     3121 gataagccat ttcgacttaa agctttctga caaggacatc aggcatgatt tccccaatcg
     3181 tggacataat attttccagg atgttcagat cgccagagag tgtgacactg gatgtgctgt
     3241 tttcacaagc tattcgcact cctcgaacga gataactgct gacttcttcc ttgcccatgc
     3301 caattgcagc cattccacca gttctttgtg gacttttgca gacgtaacca cgataatatg
     3361 ccgcaatgat ggcttccttc atggtcaggg cacccgcagc atacgatgcg gcaatttcac
     3421 cactagaatg gccaacaact gcagatggag ttatgctcca cattgctaga agatcgacca
     3481 gagcaatttg taaggctgtg cagattggtt gggagtactc agctttgcca agaattgatt
     3541 tatcatccca gttcaagaga gcatatattt cattgtaagt cggatgcgac tcaggcagct
     3601 caagtagttt taccttcgat cgaccatgac ggtgcgtgtt ccaaacgctg aagaactcta
     3661 tccattgatt cgatagtacc taagatagat gggtattgga gcatcagctc ttttcccatg
     3721 tgaaccctaa agaatggttc atttagcatt gcccgagaat aatctcatac attttatcac
     3781 caagtgataa atctggtttt tacaacgtat ctgtgagaaa aaaacagggc gaagagggta
     3841 gcaaagatgg agaatagtta ccattgtgca ccctgcccgg tgaatataaa agctgcttga
     3901 cgtagaccct ggaacttggt ctggggtgaa actacgaagg acgtagagtc atttttgaca
     3961 acacagtaac ttctcaactt cagatgctct cttctttggg caagagtcta tactaaatcg
     4021 tcgaggcggt caggatgctt tctgaagtag cccttaatgt tctcagcgac ccttttcaat
     4081 gactcggggt gatttgctga aaagaacaaa agaattttgc gtcgcttttg ctgctttata
     4141 gtcggagttg aagccgaatc tggagtatta aggccaaacg aagccgcaga atcgatgacg
     4201 aattgagaca aatgttagct ggccagaatt atttcaacca aaggttttga gcttgcatgg
     4261 gcattagaac caccgatgcc ataagaattc acgctcactc gttccgcgcg attttctggc
     4321 catggaaaag gttctacagg tacgactagc cttgcacttt ctcacggaac tatggatatt
     4381 tagcatttct ctatgtgttt ctctagtttg gccaggattg gtaatgacct acttcctggg
     4441 tttggatttt cgaacttgat gtttggaatg attgtccggt tctcaagcga taggactgct
     4501 ttgataatac tagtgattgc agcagctccc tcgctgtggc ctaggtttgg tttgatctat
     4561 gctgttttag catttaatta aattgagaat cgatttgaac ttatagttcc aaggtataca
     4621 cccttatttc caaagcaatc gcagattgct ttagtctcaa tagggtcacc aatttttgta
     4681 cctgtgccgt gagcctccac cattgctgtc tctgacagat ctaagcctgc agcgttgtat
     4741 gcttggcgga tccagccttg tacgcttcag gatttggcat ggccatgcca ttagttctgc
     4801 cgtcggcatt gctcgctgaa gatcgaatga ttgctcggat ggggttcttg tctctgatag
     4861 cctcgtcaag gcttttgata tagagagcag taacgctctc tcctcgagca tatccgtcgg
     4921 cagaagcatc aaaagacttg gatgaccctt caggggaaag tgccattttt acactcatgc
     4981 tgatggtcat acctggagct aggatcaaac tcgttccgca tacaattgcg gcggaaattt
     5041 ctcccagccg gattgcttgt aatgcctggt gcaagcctag ccccgcagaa gagcatgcac
     5101 tcttgataat catactatcc attcgttaga ttcattccct ggcaaattat gtgatatagt
     5161 gcgtttttca agtataccta ggccccttaa gatcatattc atatgagatt cgattaggca
     5221 gagcaaagtc aaggccaccc agtactcgat acggattgta ctcgtgggtg tccttgtgtt
     5281 gcaagtcttg ccaatcttcg gagaacatgc caacgtaagt gccaatgttc tttcctcgcc
     5341 attctgtctc acctgaactc tcaaatgctt ctctgactac ctcaagcact aatctatgat
     5401 ttgggtcaac ttgttccgct tcagcaggtg tgagagtaaa cattgatagg tcgaatttgg
     5461 aaaagtccac gtcgttcata aagtagccat gcttggtact tatagtcccg tgtttgctat
     5521 gtgcactgta ataagcatca atgttgtatc gatcttccgg aatcgttgac cgagcgtccc
     5581 ccttgttaat caggaaatcg tacaaagctc tgtcgttgtg gattccacca ggcaatctca
     5641 ttcccatacc acatatggct actgggacct gctcggcgtc tcgagtaaca tgtggcactt
     5701 tctgtattcc attcataact gctctctaat gatgcaaatg ctcctaatag ccgttcacac
     5761 cattgacatg gtttttgaac cagttcgtgt gggcgttgat ctctatcgtt cgatactgct
     5821 cttgagcctt tgccgatcgg tttcaataga tgaaaagcct ttcaatataa agaaatgcaa
     5881 attgaatggg ggccctaagt gccgaagata attctcagcg atgtatcaat gtaaacagat
     5941 ttcaagttaa tcaggtagtt tgactctgct aactctgtct gacgagagcc gactttatac
     6001 tgacgtgaaa ataacaaaac ggggtttggt gagccattcg ctttatggaa tgaatctaga
     6061 gcattctgct tttctgattg gtcacggtgt aaaggaatag tgaccctggc caagaggagg
     6121 gagaacagca ttgacaggca gggatatttg attagaaaca ttgcttcatt catgtcagtt
     6181 cgaatacctt ttcctgtgac aggtattttt cttcgtacat gacccggtca ccattttttg
     6241 ggttatgtaa tgggagctcg tgagcactag tcagctcgta tactgggtac agttgcagtt
     6301 agtgaaaaag tccttcgtac agccacatgt accacctcat ctacttaccc ttgggttttc
     6361 gattggtgga tagttgagtt tcttactctg aagaactcga tgaagcaata gggctggttg
     6421 ttgattccga cgagtgcaat tagtacttag attgggaatc ttgaacttgc cagctatatt
     6481 gccgtgagga gtcgaggttg tatcaaatcg ttctcagaac agcgaaaacg ggtttctttt
     6541 cccatgtttg gtgaccgcct ttccctaatg tatatccttc ggtcctcgct gtctctcatc
     6601 agcatccccc aacaaccgat cacgctacta tcgtacggaa cagaccctgg taaccggtca
     6661 tactcgaacc gacacgaatg aaatcgtatg atatgtacgc atgtttggcg taggaaaaga
     6721 cgttgaatgg atgatttttc agcttatacg tgaaacaatg tcttaacatg cggaatttct
     6781 ttctatgacg taattcattc agctgatgta gtgtaactat gggcttaacc tcggcatttc
     6841 tttcgtagaa aaaaatctat gaactatctt acatatgcag gatttgcctc gatcagaccc
     6901 tttaatagta gttggttgaa ttgcattgta ggattttttg gtgtggttga ttgtgattgg
     6961 ctgaatgatg atgctaaacg gattaagcga tatgttttct cgtgtgtaat ataccgtgat
     7021 aacagtaaaa agtaattccg atacgagtcc gaagccttgt tgtgggttgg tagcggattc
     7081 gaaattttgg tggtgaaagt gagttttggc gggaggccaa atgtgtccag gccctctaca
     7141 cagaattaca cacaaaaaat atcgcttaat ccggttagca tcatcattca gccacttaca
     7201 atcaaccaca ccaaaaaaat cctacaatgc aattcgacca accaaccatt caaccaacta
     7261 ctatgaaagg gcctgatcga ggcaaatgca ggatgccgtt gtgctgtctg tgaaacattc
     7321 gattatcatt ctggacactt gactcgagga tacacaagcg ccctgccaag gctgtttgac
     7381 tagctcacta ggtaggtaca aggggcttac ccagctaggc ggactgtgac tagcatggaa
     7441 cgagctagac acttctgtac cgctcctcaa atcctcaaat cctctactct gtacacgctg
     7501 ctcctgtcac gttacaacca aacgttacat tttctgttct cacataacgt atgagttgat
     7561 gatcgacgtt tagcagcaga tagacactct acgtcggcaa gagtttcgga gactgcccgc
     7621 tggcagctct agccgcgcag cgatgtgcgc agaagatagt gtattgtcat cctaacgacg
     7681 acactttgcc aagcggccta ttaccgtcaa tcatagtata gcagcaatca gcaccgtctt
     7741 agtccgaacc tgacagcagg caagttggcg gcctgaattc cccagagctt ttgccgatct
     7801 ccctccaccc acagaacctc cggcatccag tatcccctgc caaatttgta tgtgtgagaa
     7861 aatcagctaa ccctagtagg atctacatgc actcgcatcc tgctcgactt ttggccagta
     7921 caatgaaggt ggatacagag gttaggaagc gccttgtaca gcgaatccac ttgcagttcg
     7981 tctaaagtag caaaaagatt gattcttgag attctttgac cgatggtttt tctttttgaa
     8041 gcagcgcttc ttcaactgct taacaagcct tcccgtagtc tccattcatt ttgatttact
     8101 ctctctgggt tggatcttat ttccgtacat tgcctatcca gagtgaaatt actttcccgt
     8161 tccaaacttc tgatcgcccc tcaagcttgc aaaaatcaca gaattgttaa tgctgaagat
     8221 atctgtgctt cttgttcact aaccgtcgcg atgtcttcta aagttcatct cgagggctta
     8281 ttcctcactt tccagtctct cctctttttt gctcttccga tcgcagcttt catagtgttc
     8341 gcggttcttt atgctgcgca ttcgaatgcg aacccatccg ttccattgta cgtgccagaa
     8401 acatcagctg cggggaatca aaagaaaaga tggatgtttg actcagtcag tctactgcag
     8461 gaggcataca aaaaggttcg agataataac agcgtactcg ttcttatcta ccgttgacca
     8521 cttcatagtt ctacggcaag cccttcagag tttggacaac agaaggggta caatttgtca
     8581 ttcccccaga ttatgtggat gaactgaaga tgctacttga ccacacattt ccatctgcac
     8641 ttcgcaatgt acggcctatt gagccatcta agttagacta tgggcatgtc gttatgaaga
     8701 acgatctaaa caagaatatg ggtgagcttt gttggcagaa gactagatta atggtttaaa
     8761 actcctgacc ttcagatatt taggaagagt ttttccagaa gtacgtgatg aagtcggtgt
     8821 tgtgtttcct ctcgaatttc cggaatgcaa aggtatgcat cttgcacgtc tgaagcagga
     8881 ccttttgcct aatcaaagga aatagattgg tttcctattc aagtgtaccc aaaggtgttg
     8941 cggctcgtaa gtcgagttaa tggaaagatt tttgttggaa atggccttca ccaaaatgaa
     9001 gagtggatca aaataagttg caatgtaagc actataaaaa aataacaacc ctcatgcctg
     9061 tttgcttacc cgtgacagta cacgagaaat gtctttctct cctctgcaaa actcagattt
     9121 tttcatccct ggcttcgccc catcgtacaa tacttcatcc cagaacttcg aaccgtctgg
     9181 aagtgtaacg ccaaagcgcg ggaactcctc gctccgatca ttcagcaaag agcaactcaa
     9241 gaaagaaatg aagattacaa aaagccaaat gatgccatcg agtggctgag agaacttatc
     9301 ccagaactag acaaaaatga tccccacttc catggaattt cacagcttgg tattggagcg
     9361 gtgtcggtga ataccacgag ccagttgatt accaatgcga tattcaacct tgctacttat
     9421 cctgaatatg tcccgatttt gaaggaggag atagattccg tgcttgaaga gtctggggga
     9481 gaatggactc ttgagagcat ggggaagctg aagaagctgg acagttttat gaaggagact
     9541 ttgcggtaca acgggcattt aactggtgag taccgactac attatcgatt attataagtg
     9601 tactagaaca tgtcttttaa cagccacctt ccaacgaaaa gcactccgac cgatcactct
     9661 ttccgacggg acttacatac cttctggcac ctttacattt ccccccgtga acgcaataag
     9721 cttcgaccca aacatctacc cggacgcgaa tacttttgac ggcctgcgct tctaccacct
     9781 tcgacaggcc tcgctggacg atgagaaaaa gtatcagctt acatcgatta ccaaaacgca
     9841 gatgcagttc ggtagcggcc gacacgcttg tccgggaagg tggttcgcca gtcaccaaat
     9901 caaattggtg cttgcggcca tgattgatca atatgagctg aaattgaaag atggcgaggg
     9961 aagaccaaag agtattgtgt ttcagatcaa tcaatttccg gacccaaagg cggagataat
    10021 gttcaaaaac aagaaatatg gcgatcaggg agggacggac tgattggttt gtattgactc
    10081 tcttattttc tcttaatgtt tctagactaa cggtaagatc gactgctgat agctgagatc
    10141 cgcaaatcat ggctacatca tagccacttc caagttctca ttgcaatttt gcacaatcca
    10201 tcgacattgt aattcggaag accaaaggta tcggagaaac ttcccaacaa gacttgcttt
    10261 tattttgtta ctctcagacg actctcccaa gcaacttcgg ggatcaagaa cgagagtcta
    10321 tgaggtagca caagaattgt tggaaaagag tagcgaagtt atagcgcttt atcatcaaaa
    10381 cgtctcattg ttttctccac catctgcagt aactggtatc atatttcgaa gttgcttgat
    10441 aaccccgtca acgtcatagc ctgtcccatt gtcattgtct atcaaacatc tcgcgacggg
    10501 gttcattatt tgaagaatgc gcattgtgcc aacgcggtcc gttttgacct tcagcgcgat
    10561 agactccaat gttttgacgg tcacggtagt gttgtgtctg tggctcccat atcagtaacc
    10621 ttgtgaagta tgctatgatg ggccatacat catgtttgcc attttcgtag agcataaaag
    10681 taatacgctc ggcccaagag cattcgtcag taacaaccat ctctttccgt aacgttttct
    10741 gtcatgaaac tttactcgca ggtccgattt tcttctatta tcaaagatct tccattcttt
    10801 gtgtatgctt tcaaggatgg catcaatgat gacgctggca cagcctcggc cgatagtttt
    10861 agcatgactg ttttgacttt gtcgttcgta tgccttggta tactccacgt ggaggcgaat
    10921 gagagctatg cggtttcgga tggcatcatc acccattctg acgtcaagct gacagacgga
    10981 agagtaagcc agctccagtt cttgaaatac ggacgttccg acagctggct tcaggaattg
    11041 ttcatcactc cacaaagcgt ctctcttcca ccgcgggagt ctcatttcca gaaacggcag
    11101 gtaatcctct ctcaagattt tttgagatgc ggcatccacc gccggattag tcgtgtttga
    11161 cgagttgttt ttgatccgag gcggattgta gggtcccggc tgaaggcatg atgattgatt
    11221 ctgtcgctgc aactgggtgt gagatgaaga agccgaagga ccctgaatgc ttagcgccga
    11281 tcttccaaag tcccttgtgc tgggactatt tggcccagaa ctggtgtttt ctgctcctga
    11341 aacgtctgaa accagaaagg caccttgttc actgcttgaa atctcaagac aatctccggc
    11401 agttgacaca gaagggcttc caggagtcac gccagaagtg atcggagaca acgtcgagac
    11461 ggccaggaga ctttgattaa tttcgtcggc aaatggtcca agctcgttgt tgagctgttt
    11521 aaaatctact gacttcgaag agctaatttc tgatggatat gctgatgtaa ttgtattccc
    11581 acggctgtgt aaagatggtt ccgagtctac cggcatccaa tccgaagctg cagctgggga
    11641 aaagcttata agactggccg cggggagaga gctcggagct gatgcgctca tgttcaggtc
    11701 agtaactagg attgcagatc tgcaaccaca cacatacagt ctggaatttc aaattcccac
    11761 gttcttagtg gagacttgtc gggataagga gcgtccaaag tcgtcgttcc gacatatgtc
    11821 ttgattggtc aatacgtgga atctcatttt ggtgtatggg gtgtaatacc tgagtgtcat
    11881 gaagaccgaa tattccacct tcacctaacg atgtatcatt ttctcttgtt gcatccacgc
    11941 accagtcagt tgagtccacg gtgctgaaca ccttgcttgt tgactcttga aaggcattcg
    12001 atggactttt tgatctgaaa cacaaaaatt tatgattagc cgagtgtgac caaaattatt
    12061 ccgaaaatcc atgtaaagag tgagtgatat atacgatatt tcacatatta gtgagagaaa
    12121 tggcttagag agatgcatgc cagtatcttc cgtatgctga atctctattc tggagggtcc
    12181 gatcagggaa atgttattac tatggaggaa cgaatttatc atgtcgagaa attgtacacg
    12241 agtgctggta gtagcggaaa agaaaggaac ttgcggcagg cgaggaggct ctttgtcaaa
    12301 catggcgatt ctaatactag taaaaccgga gaagagggtc gatcgtcttg gcgtggtaac
    12361 tagtaacgcg aacttgaatt tcaagctttt atatctctaa atcgataggt gacgttggca
    12421 attatggtag cggacatctt aacgctataa actccctcta gggagcatcg cccgactaag
    12481 accaaagtgg aataggggct tctcttatca ctctctcctc tcccacaaaa tacatgttca
    12541 ttctctttag taaacgcttt ccgtcagtca tggaggatat ccgtatgtac catccacctt
    12601 cgatcttgaa cgagggacga gcggaggtac atggaaggaa tatacccggt acggcgatac
    12661 cccgcctgat gcggtcagtc cttgacacaa aatctcttgt ggagttcggt gagccgttcg
    12721 aaggttccac tgcattaaaa atgacaaata tcgagaaatc ctgagggcgt catcgagacc
    12781 cggtaacagc ggatcgagag ttaggattta gcgtcatatt tgaaagtctg acgcctgcag
    12841 cagacaccga ggagaaggca ctggaggtac aatccgactg ccgctgacga gttagaagac
    12901 tgatcccaat tatgaggcaa actacgtgaa aggcgactta ccctcggggc cgagatacag
    12961 gctacgcagg gtaaggagta gggagttggc acgatgtgac agtcacagga gatatgggag
    13021 aaaaggtatg tgtcgctcga aaggcagact aattgctacc ctttcaaaag tgcttgcttc
    13081 tatctctata tagctactcg agcagagggt tgacccctaa gaggtatgac tccttctaga
    13141 agaagagatt gcttgatttg aaatcaagga cacatggctg ctctcagtct tccgtgctta
    13201 tgctggaaga tagcagtcct tcggtccctc ggtgattcga aatcatgctt ggaaatcatg
    13261 cttggaaatc atgcttggaa atagccgttt cgatatgctt cgattcgcca ccgtcgaaac
    13321 gtcagcttag aaatcgagtt tgaactcgct tcgc
//
