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Home • Arthroderma benhamiae CBS 112371
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Hyphae and microconidia of A. benhamiae on human hair and human keratinocytes. Fluorescence microscopic picture (laser scanning microscope LSM 5 LIVE, Zeiss, Jena) of hyphae and microconidia stained with fluorescent brightener 28 (Sigma, USA). Scale bar: 5 µm. Burmester et al. Genome Biology 2011 12:R7
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Hyphae and microconidia of A. benhamiae on human hair and human keratinocytes. Human keratinocytes with germinating A. benhamiae microconidia. Scanning electron microscopy image. Scale bar: 10 µm. Burmester et al. Genome Biology 2011 12:R7

The genome sequence and gene predictions of Arthroderma benhamiae were not determined by the JGI, but were downloaded from Broad Institute and have been published (Anke Burmester et al., 2011). Please note that this copy of the genome is not maintained by the author and is therefore not automatically updated.

The two dermatophyte species Arthroderma benhamiae and Trichophyton verrucosum are both zoophilic, yet the natural reservoir of T. verrucosum is almost exclusively cattle, whereas A. benhamiae is usually found on rodents, in particular guinea pigs. The two species also differ in their ability to grow under laboratory conditions, with T. verrucosum being very difficult to cultivate at all. Conversely, A. benhamiae is comparatively fast growing and produces abundant microconidia. As a teleomorphic species, the fungus is even able to undergo sexual development, including the formation of sexual fructifications (cleistothecia). These characteristics, together with the recent establishment of a guinea pig infection model and a genetic system for targeted gene deletion (P Staib and colleagues, manuscript submitted) for this species, suggest A. benhamiae is a useful model organism to investigate the fundamental biology and pathogenicity of dermatophytes. Despite the above mentioned phenotypic differences, A. benhamiae and T. verrucosum are phylogenetically very closely related, and both induce highly inflammatory cutaneous infections in humans, such as tinea corporis. Therefore, a genome comparison of the two species should reveal common basic pathogenicity-associated traits.

 

 

 

 

 

 

 

 

 

 

 

Genome Reference(s)