Home • Aspergillus niger ATCC 13496 v2.0
Photo of Aspergillus niger ATCC 13496 v2.0
Aspergillus niger van Tieghem ATCC 13496 fruiting bodies taken with a dissecting microscope, provided by Adrian Tsang.
Photo of Aspergillus niger ATCC 13496 v2.0
Aspergillus niger van Tieghem ATCC 13496 provided by John Gladden

Understanding how cellular machinery can be altered to promote enhanced expression and secretion of native enzymes is of great importance to biotechnology. On a broader perspective, characterization of fungal secretion mechanisms is also for scientific fields, such as investigations into fungal pathogenicity. In industry and in the lab, enhanced production of enzymes is often achieved through mutagenesis and selection for enzyme hyperproducer mutants. One such Aspergillus lineage, Parent ATCC 13496; Mutant ATCC 13497, has been generated for the hyperproduction of an important enzyme glucoamylase. Sequencing of each strain in the lineage will enable the identification of the genomic changes that endow the mutants with the hyperproduction phenotype. Identification of these gemomic lesions will help elucidate the mechanisms behind enzyme hyperproduction.

This is an improved draft assembly of Aspergillus niger ATCC 13496. Distinct from Aspni_bvT_1, this strain has been sequenced with PacBio and annotated using a combination of PacBio transcriptomic data (IsoSeq) as well as new Illumina RNAseq data.