This micrograph shows histopathologic changes that reveal the presence of the fungal agent Blastomyces dermatitidis. Photo credit: Blastomyces dermatitidis Sequencing Project, Broad Institute of Harvard and MIT (http://www.broadinstitute.org/)

This genome was sequenced by the Broad Institute.

Blastomyces dermatitidis is the causative agent of blastomycosis, a geographically widespread systemic mycosis of humans and other mammals. Although blastomycosis occurs worldwide, it is most common in North America and is endemic to the Ohio and Mississippi River Valley regions. After mild infection, blastomycosis can undergo a prolonged latent period and reactivate in individuals with compromised immune systems, as is the case in AIDS patients. Untreated acute blastomycosis frequently progresses to severe pulmonary disease, with potential for dissemination to other organs, skin and bone.