Home • Fusarium verticillioides 7600 v2
Photomicrograph showing the conidiophores and conidia of Fusarium verticillioides.
Photomicrograph showing the conidiophores and conidia of Fusarium verticillioides.
Image from the CDC Public Health Image Library.
Image credit: CDC/Dr. Libero Ajello (PHIL #4011), 1978.

The genome of Fusarium verticillioides was sequenced by the Broad Institute and the text below is copied from there. In order to allow comparative analyses with other fungi, a copy of this genome was imported into MycoCosm.

Fusarium verticillioides is the causal agent of kernel and ear rot of maize. This destructive disease occurs virtually everywhere that maize is grown worldwide. In years with high temperatures, drought, and heavy insect damage, the disease can significantly diminish crop quality.

The most significant economic impact of F. verticillioides is its ability to produce fumonisin mycotoxins. Various diseases caused by fumonisins have been reported in animals, such as liver and kidney cancer as well as neural tube defects in rodents (Howard et al. 2001, Seefelder et al. 2003), leukoencephalomalacia in equines (Wilson et al. 1992), and pulmonary edema in pigs (Kriek et al. 1981). More importantly, epidemiological correlations have been established between human esophageal cancer and the consumption of fumonisin-contaminated maize in some regions of the world where maize is a dietary staple. In addition, fumonisins have been reported to be a potential cause of neural tube defects in humans (Seefelder et al. 2003). Due to potential health risks, guidelines for fumonisin levels in food have been established by the US FDA and by other government agencies worldwide (FDA/CFSAN, 2001). In 2003, fumonisin B1, the fumonisin produced most abundantly by F. verticillioides, was added to the California Proposition 65 List of Substances Known to Cause Cancer.

Sequenced strain information: Strain 7600 (FRC M3125=NRRL 20956), which has been used extensively in molecular and pathological studies, was selected for the genome project. This strain is available at FGSC, NCAUR-ARS-USDA and the Fusarium Research Center at Penn State. The genome size is estimated to be 46 Mb with 12 chromosomes.


Genome Reference(s)