(A) Cocultivation of Phytophthora infestans and wild type, ΔlcsA and OE::lcsF Purpureocillium lilacinum on rye agar medium. (B) Cocultivation of Ph. capsici and wild type, ΔlcsA and OE::lcsF Pu. lilacinum on PDA medium. [Photo source: Wang G, et al. (2016) PLoS Pathog; used under CC-BY-4.0]

The genome sequence and gene models of Purpureocillium lilacinum PLFJ-1 were not determined by the Joint Genome Institute (JGI), but were downloaded from Ensembl Fungi on April 11, 2020. Please note that this copy of the genome is not maintained by Ensembl and is therefore not automatically updated. The JGI Annotation Pipeline was used to add additional functional annotation to the author's chromosomes and proteins.

Purpureocillium lilacinum, a well-known bio-control agent against various plant pathogens in agriculture, can produce antibiotic leucinostatins. The scientists from the Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, and Institute of Microbiology, Chinese Academy of Sciences, sequenced the genomes of two P. lilacinum isolates (PLBJ-1 and PLFJ-1), and identified a gene cluster containing 20 genes involved in leucinostatins biosynthesis. And a new bioactivity of leucinostatins, inhibition of the growth of the notorious Phytophthora, was identified by confronting incubation with P. lilacinum. The study provided new strategies for the agricultural development of leucinostatins and improving P. lilacinum strains.