Home • Thermomyces lanuginosus ATCC 200065
Photo of Thermomyces lanuginosus ATCC 200065
Thermomyces lanuginosus ATCC 200065 grown on an agar plate supplemented with 1% soluble starch for 120 h at 45 ºC. Photo credits: Genevieve Quenneville, Sandrine Marqueteau and Marie-Claude Moisan

The genome sequence and gene prediction of Thermomyces lanuginosus ATCC 200065 have not been determined by the Joint Genome Institute (JGI), but were downloaded from CSFG on July 31, 2022. In order to allow comparative analyses with other fungal genomes sequenced by the JGI, a copy of this genome is incorporated into Mycocosm. Please note that this copy of the genome is not automatically updated. JGI tools were used to automatically annotate predicted proteins.

Thermomyces lanuginosus is a thermophile from Trichocomaceae family. It can grow up to 60 °C with an optimal growth temperature near 45 °C and pH 6.5. Thermomyces lanuginosus has been isolated from soil, decaying plant material, self-heating composts and dung of various animals (1). Several thermoactive enzymes have been characterized including xylanase (2-4), lipase (5), glucoamylase (6), alpha-galactosidase (7), phytase (8), and amylase (9). The availability of the genome of T. lanuginosus will provide a valuable information to identify new thermostable enzymes involved in lignocellulolytic processes.

Note: If you intend to publish any articles including Thermomyces lanuginosus ATCC 200065 genomic data, please contact Adrian Tsang for permission prior to publication: [email protected]


1. Singh S, Madlala AM, Prior BA. Thermomyces lanuginosus: properties of strains and their hemicellulases. FEMS Microbiology Reviews 2003, 27: 3–16.

2. Puchart V, Katapodis P, Biely P, Kremnicky L, Christakopoulos P, Vrsanska M, Kekos D, Macris B J, Bhat, M. K. Production of xylanases, mannanases, and pectinases by the thermophilic fungus Thermomyces lanuginosus. Enzyme Microb Tech 1999, 24, 355-361

3. Singh S, Pillay B, Prior BA (2000) Thermal stability of beta-xylanases produced by different Thermomyces lanuginosus strains. Enzyme Microb Technol 26: 502-508.

4. Schlacher A, Holzmann K, Hayn M, Steiner W, Schwab H. Cloning and characterization of the gene for the thermostable xylanase XynA from Thermomyces lanuginosus. J Biotechnol 1996 49(1-): p. 211-8.

5. Berg OG, Cajal Y, Butterfoss GL, Grey RL, Alsina MA, Yu BZ, Jain MK. Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid. Biochemistry. 1998 May 12;37(19):6615-27.

6. Basaveswara Rao V, Sastri NV, Subba Rao PV. Purification and characterization of a thermostable glucoamylase from the thermophilic fungus Thermomyces lanuginosus. Biochem J 1987, 193: 379-387.

7. Puchart V, Vrsanská M, Bhat MK, Biely P. Purification and characterization of alpha-galactosidase from a thermophilic fungus Thermomyces lanuginosus. Biochim Biophys Acta.2001 Nov 15;1524(1):27-37

8. Berka RM, Rey MW, Brown KM, Byun T, Klotz AV (1998) Molecular characterization and expression of a phytase gene from the thermophilic fungus Thermomyces lanuginosus. Appl Environ Microbiol 64: 4423-4427.

9. Nguyen QD, Rezessy-Szabo J M, Claeyssens M, Stals I, Hoschke A. Purification and characterisation of amylolytic enzymes from thermophilic fungus Thermomyces lanuginosus strain ATCC 34626 Enzyme and Microbial technology 2002, 31: 345-352.