Home • Yarrowia lipolytica YB419 v1.0
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Image credit: Trinh lab, University of Tennessee, Knoxville

Yarrowia lipolytica, a generally regarded-as-safe oleaginous yeast, is an emerging bioenergy microbe. It can natively produce high amounts of alpha-ketoglutarate, citrate, and neutral lipids by assimilating various substrates (e.g. hydrocarbons, ethanol, acetate, C5/C6 sugars, cellobiose, etc.) under specific conditions. A beneficial phenotype of Y. lipolytica is its exceptional tolerance to high salinity, organic solvents, and broad range of pH (pH 2-11). Screening of genetic diversity of 45 strains from ARS (NRRL) culture collection shows that the strain YB419, isolated from milled corn (maize) fiber tailings from Pekin, IL, USA exhibited robust growth in up to 75% undetoxified switchgrass hydrolysate with superior lipid production, approximately 57% higher lipid titer than the model strain CLIB89 (W29) [1].


  1. Quarterman, J., et al., A survey of yeast from the Yarrowia clade for lipid production in dilute acid pretreated lignocellulosic biomass hydrolysate. Appl Microbiol Biotechnol, 2017. 101(8): p. 3319-3334.

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