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Yarrowia lipolytica YlCW001
Yarrowia lipolytica YlCW001.
Image Credit: Cong Trinh

Yarrowia lipolytica YlCW001 is the most ionic liquid-tolerant oleaginous yeast published to date, tolerating up to 18% (v/v) 1-ethyl-3-methylimidazolium acetate ([EMIM][OAc]) (Walker et. al. 2019).  YlCW001 was isolataed after 200 generations of adaptive laboratory evolution in [EMIM][OAc] from the parent strain, PO1F (ATCC MYA-2613).  The ionic liquid-tolerant phenotype of YlCW001 is advantageous for novel biocatalysis in high concentrations of ionic liquids.

Walker C, Ryu S, & Trinh CT (2019) Exceptional solvent tolerance in Yarrowia lipolytica is enhanced by sterols. Metabolic Engineering 54:83-95.

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