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Automatic Ontology |
| ASPECT |
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| function |
| 16987 A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. | IPR013324 RNA polymerase sigma factor, regions 3 and 4 | | | 3677 Interacting selectively with DNA (deoxyribonucleic acid). | IPR013324 RNA polymerase sigma factor, regions 3 and 4 | | | 3700 The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. | IPR013324 RNA polymerase sigma factor, regions 3 and 4 | |
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| process |
| 6352 Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter. | IPR013324 RNA polymerase sigma factor, regions 3 and 4 | | | 6355 Any process that modulates the frequency, rate or extent of DNA-dependent transcription. | IPR013324 RNA polymerase sigma factor, regions 3 and 4 | |
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