The genome and gene models of Candida albicans SC5314 were downloaded from NCBI on Oct 21, 2016. JGI tools were used to add functional annotations to the gene models. Please note that this copy of the genome is not maintained by NCBI and is therefore not automatically updated. In order to allow comparative analyses with other fungal genomes sequenced by the JGI, a copy of this genome is incorporated into Mycocosm.
Candida albicans is a dimorphic fungus that grows both
as yeast and filamentous cells and one of the few species of the
Candida genus that cause the infection candidiasis in
humans. C. albicans is a common member of human gut flora
and is detectable in the gastrointestinal tract in 40% of healthy
adults. It is usually a commensal organism, but can become
pathogenic in immunocompetent individuals under a variety of
conditions. Overgrowth of the fungus results in candidiasis
(candidosis). Candidiasis is often observed in immunocompromised
individuals, including HIV-infected patients. It commonly occurs on
mucous membranes in the mouth or vagina, but may affect a number of
other regions. C. albicans is responsible for 50–90%
of all cases of candidiasis in humans. Systemic fungal infections
(fungemias) including those by C. albicans have emerged as
important causes of morbidity and mortality in immunocompromised
patients (e.g., AIDS, cancer chemotherapy, organ or bone marrow
transplantation). C. albicans biofilms may form on the
surface of implantable medical devices. In addition,
hospital-acquired infections by C. albicans have become a
cause of major health concerns.
.
Genome Reference(s)
Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S
The diploid genome sequence of Candida albicans.
Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. doi: 10.1073/pnas.0401648101
van het Hoog M, Rast TJ, Martchenko M, Grindle S, Dignard D, Hogues H, Cuomo C, Berriman M, Scherer S, Magee BB, Whiteway M, Chibana H, Nantel A, Magee PT
Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.
Genome Biol. 2007;8(4):R52. doi: 10.1186/gb-2007-8-4-r52
Muzzey D, Schwartz K, Weissman JS, Sherlock G
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.
Genome Biol. 2013;14(9):R97. doi: 10.1186/gb-2013-14-9-r97