This Chaetomium globosum portal is based on the
assembly, gene modeling, and data from the BROAD
Institute Chaetomium globosum Database. From that
site:
Chaetomium is a genus of filamentous fungi (Phylum
Ascomycota, Class Sordariomycetes) encompassing species that
typically possess densely setose, ovoid to pyriform ostiolate
ascomata, clavate asci and pigmented, one-celled ascospores (Domsch
et al. 1993). Species of Chaetomium are important in the
decomposition of plant and other cellulose-rich materials, and can
be isolated easily from dung, plant debris and soil. The genus
contains a number of species capable of growth at elevated
temperatures as well as a few species that cause infections in
vertebrates. Chaetomium globosum, the type species of the
genus, can be isolated easily from decaying plant material, seeds
and other cellulosic substrates. It is the most frequently isolated
and cosmopolitan of the over 150 species of Chaetomium
described to date (Domsch et al. 1993).
Chaetomium globosum is a medically important fungus and
is encountered typically as an agent of skin and nail infections in
humans. This species more rarely causes cerebral and systemic
infections, but such mycoses have high mortality rates,
particularly in immunocompromised patients (Serena et al.
2003).
Chaetomium globosum is important to human health as a
contaminant in indoor environments since it is known to produce
mycotoxins (Nielsen et al. 1999; Pieckova 2003) and acts as an
allergen.
References:
- Domsch, K.H. et al. (1999). Compendium of soil fungi. Volume 1. Academic Press, London, UK.
- Nielsen, K.F. et al. (1999). Production of mycotoxins on artificially and naturally infested building materials. Mycopathologia 145(1):43-56.
- Domsch, K.H. et al. (1999). Compendium of soil fungi. Volume 1. Academic Press, London, UK.
- Pieckova, E. (2003). In vitro toxicity of indoor Chaetomium Kunze ex Fr. Ann. Agric. Environ. Med. 10(1):9-14.
- Serena, C. et al. (2003). In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization. Antimicrob. Agents Chemother. 47(10):3161-3164.
Genome Reference(s)
Cuomo CA, Untereiner WA, Ma LJ, Grabherr M, Birren BW
Draft Genome Sequence of the Cellulolytic Fungus Chaetomium globosum.
Genome Announc. 2015 Feb 26;3(1):. doi: 10.1128/genomeA.00021-15
Berka RM, Grigoriev IV, Otillar R, Salamov A, Grimwood J, Reid I, Ishmael N, John T, Darmond C, Moisan MC, Henrissat B, Coutinho PM, Lombard V, Natvig DO, Lindquist E, Schmutz J, Lucas S, Harris P, Powlowski J, Bellemare A, Taylor D, Butler G, de Vries RP, Allijn IE, van den Brink J, Ushinsky S, Storms R, Powell AJ, Paulsen IT, Elbourne LD, Baker SE, Magnuson J, Laboissiere S, Clutterbuck AJ, Martinez D, Wogulis M, de Leon AL, Rey MW, Tsang A
Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris.
Nat Biotechnol. 2011 Oct 2;29(10):922-7. doi: 10.1038/nbt.1976