Home • Nosema bombycis CQ1
Photo of Nosema bombycis CQ1
Mature spores of Nosema bombycis CQ1 under light microscopy (X400) [Photo credit: Prof. Zeyang Zhou]
Photo of Nosema bombycis CQ1
Ultrathin section of Nosema bombycis spore under transmission electron microscope [Photo credit: Prof. Zeyang Zhou]

The genome sequence and gene models of Nosema bombycis CQ1 were not determined by the Joint Genome Institute (JGI), but were downloaded from Ensembl Fungi on April 11, 2020. Please note that this copy of the genome is not maintained by Ensembl and is therefore not automatically updated. The JGI Annotation Pipeline was used to add additional functional annotation to the author's chromosomes and proteins.

The microsporidian Nosema bombycis is the pathogen that causes silkworm pébrine disease, which leads to enormous economic losses to sericulture. N. bombyis is also the first microsporidian species identified. Compared to other known Nosema species, N. bombycis can unusually infect a broad range of hosts. Besides horizontal transmission, N. bombycis can also be vertically transmitted via invading into insects ovary and embryo. The genome of N. bombycis was estimated to be approximately 15.3 MB, organized in 18 chromosomes. N. bombycis CQ1 (NbCQ1) is a strain isolated and identified from infected silkworm in Chongqing, China. The genome sequencing of the NbCQ1 was completed by the State Key Laboratory of Silkworm Genome Biology, Southwest University. Genomic DNA and mRNA of the NbCQ1 were extracted for constructing a plasmid library with 1.5-2Kb inserts, a miniBAC library with 30-50Kb inserts, a Solexa DNA library and cDNA libraries. In result, 6.7X Sanger reads from the plasmid library, 0.4X miniBAC ends and ~28X Solexa reads were sequenced for genome assembling and annotating. Finally, 1607 scaffolds with a total size of 15.8 MB were assembled from 3558 contigs, from which 4468 coding genes were predicted (Pan, et al, 2013). The genome of NbCQ1 was found to be high repetitive and redundant for containing large quantities of gene duplications and transposable elements, which led to the genome expansion of N. bombycis.

Genome Reference(s)


  • Guoqing Pan et al. Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation. BMC Genomics. 2013, 14: 186.