Home • Ogataea parapolymorpha DL-1
Photo of Ogataea parapolymorpha DL-1
Micrograph of a budding O. polymorpha cell, grown in a chemostat under methanol conditions. The cytosol is crowded by peroxisomes (after Gellissen et al. 2005).
By Prof. Dr. Gerd Gellissen
[CC BY-SA 2.0 de]via Wikimedia Commons

The genome and gene models of Ogataea parapolymorpha DL-1 were downloaded from NCBI on Oct 21, 2016. JGI tools were used to add functional annotations to the gene models. Please note that this copy of the genome is not maintained by NCBI and is therefore not automatically updated. In order to allow comparative analyses with other fungal genomes sequenced by the JGI, a copy of this genome is incorporated into Mycocosm.

Ogataea parapolymorpha belongs to a limited number of methylotrophic yeast species – yeasts that can grow on methanol. It is used as a protein factory for pharmaceuticals. The range of methylotrophic yeasts includes Candida boidinii, Pichia methanolica, Pichia pastoris and Ogataea polymorpha. Three O. polymorpha / O. parapolymorpha strains are known. They have unclear relationships and are of independent origins. They are found in soil samples, the gut of insects or in spoiled concentrated orange juice. They exhibit different features and are used in basic research and to recombinant protein production. Strains CBS4732 and NCYY495 can be mated whereas strain DL-1 cannot be mated with the other two. Strains CBS4732 and DL-1 are employed for recombinant protein production, strain NCYC495 is mainly used for the study of nitrate assimilation.