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Home • Orpinomyces sp.
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Orpinomyces sp. C1A. credit: Noha Youssef et al

The genome sequence and gene prediction of Orpinomyces sp. were not determined by the JGI, but were provided by Noha Youssef (noha@okstate.edu) and have been published (The genome of the anaerobic fungus Orpinomyces sp. strain C1A reveals the unique evolutionary history of a remarkable plant biomass degrader). Please note that this copy of the genome is not maintained by the author and is therefore not automatically updated.

Anaerobic gut fungi belong to the phylum Neocallimastigomycota, an early divergent basal fungal lineage and reside in the rumen, hindgut, and feces of ruminant and non-ruminant herbivorous mammals and reptilian herbivores. Analysis of a Neocallimastigomycota genome is extremely relevant form multiple reasons:

Orpinomyces sp. strain C1A was isolated from the feces of an Angus steer. The genome of Orpinomyces sp. strain C1A, was sequenced using a combination of Illumina, and PacBio SMRT technologies. The genome exhibited multiple interesting genomic features such as low GC content, proliferation of intergenic repeats. It also contained multiple genes and pathways that are absent in Dikarya genomes but present in basal fungal lineages and/or non-fungal Opisthokonts. These included genes for post-translational fucosylation, the production of specific intramembrane proteases and extracellular protease inhibitors, the formation of a complete axoneme and intraflagellar trafficking machinery, and a near-complete focal adhesion machinery. Finally, analysis of the lignocellulolytic machinery in the C1A genome revealed an extremely rich repertoire, with evidence of horizontal gene acquisition from multiple bacterial lineages.

Genome Reference(s)