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Home • Tolypocladium inflatum NRRL 8044
Cyclosporin, the immunosuppressant drug produced by T. inflatum.
Image by Yikrazuul. Source: <a
href="https://en.wikipedia.org/wiki/Ciclosporin">https://en.wikipedia.org/wiki/Ciclosporin</a>
Cyclosporin, the immunosuppressant drug produced by T. inflatum. Image by Yikrazuul. Source: https://en.wikipedia.org/wiki/Ciclosporin

Tolypocladium inflatum is a member of the Ophiocordycipitaceae family (Ascomycota), a lineage known for their parasitism of insects. T. inflatum is commonly found in the soil, where it produces asexual reproductive structures, but upon infection of scarab beetles it will form a compound ascocarp which arises from the host beetles corpse. T. inflatum was originally isolated in Norway, and has become famous for its production of the immunosuppressant drug cyclosporin (see image).

The genome sequence and gene models of Tolypocladium inflatum NRRL 8044 were not determined by the JGI, rather they were acquired from Jason Stajich in June, 2016. In order to allow comparative analyses with other fungal genomes sequenced by the JGI, a copy of this genome is incorporated into Mycocosm. JGI tools were used to automatically annotate predicted proteins. Please note that this copy of the genome is not maintained by the Stajich lab and is therefore not automatically updated.

Genome Reference(s)