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Home • Yarrowia lipolytica FKP355 v1.0
Image Credit: Bruce Arey and Kyle Pomraning, Pacific Northwest National Lab
Image Credit: Bruce Arey and Kyle Pomraning, Pacific Northwest National Lab

Yarrowia lipolytica is a non-conventional oleaginous yeast capable of dimorphic growth and has been isolated from a wide variety of substrates including soil, waste water, olives, cheese and other dairy products, industrial oil processing facilities, aviation fuel, livestock and human skin. Historically, Y. lipolytica has been used as a model to study dimorphism, mitochondrial complex I, peroxisome biogenesis, and lipid metabolism. It is genetically tractable and a wide variety of strains and genetic tools have been developed for its study. Y. lipolytica is adept at utilizing and storing hydrophobic substrates, such as lipids, and is enjoying a surge in research directed at lipid production and metabolism. Strain FKP355 (matA; leu2-270; ura3-302::URA3+; xpr2-332; axp-2; ku70::hph+) is a non-homologous end-joining mutant derived by transformation of Po1g (Madzak C, Treton B, and Blanchin-Roland S, J. Mol. Microbiol. Biotechnol., 2000).

Madzak C, Tréton B, Blanchin-Roland S. Strong hybrid promoters and integrative expression/secretion vectors for quasi-constitutive expression of heterologous proteins in the yeast Yarrowia lipolytica. J Mol Microbiol Biotechnol. 2000 Apr;2(2):207-16.

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